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The world""s most highly regarded reference text on the mechanisms and clinical management of blood diseases

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields.

The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis.

Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

1. Initial approach to the patient: History and physical examination
2. Examination of blood cells
3. Examination of the marrow
4. Consultative Hematology
5. Structure of the marrow and hematopoietic microenvironment
6. The organization and structure of lymphoid tissues
7. Hematology of the fetus and newborn
8. Hematology during pregnancy
9. Hematology in older persons
10. Genetic principles
11. Genomics
12. Epigenetics
13. Cytogenetic and Genetic Abnormalities
14. Metabolism of Hematological Neoplastic Cells
15. Apoptosis and Autophagy
16. Cell cycle regulation and hematological disorders
17. Signal transduction pathways
18. Hematopoietic stem cells, progenitors, and cytokines
19. The inflammatory response
20. Innate immunity
21. Adaptive immunity
22. Pharmacology and toxicity of antineoplastic drugs
23. Hematopoietic stem cell transplantation
24. Treatment of infections in the immunocompromised host
25. Antithrombotic therapy
26. Immune cell therapy
27. Vaccine therapy
28. Therapeutic apheresis: indications, efficacy, and complications
29. Gene transfer for therapy
30. Regenerative Medicine: Multipotential cell therapy for tissue replacement
31. Structure and Composition of the Erythrocyte, Absorb former 30 Composition of Erythrocyte.
32. Erythropoiesis
33. Erythrocytes turnover
34. Clinical manifestations and classification of erythrocyte disorders
35. Aplastic anemia
36. Pure red cell aplasia
37. Anemia of chronic disease
38. Erythropoietic effects of endocrine disorders
39. The congenital dyserythropoietic anemias
40. Paroxysmal nocturnal hemoglobinuria
41. Folate, cobalamin and megaloblastic anemias
42. Iron Metabolism
43. Iron deficiency and overload
44. Anemia resulting from other nutritional deficiencies
45. Anemia associated with marrow infiltration
46. Erythrocyte Membrane Disorders
47. Erythrocyte Enzyme Disorders
48. The thalassemias
49. Disorders of hemoglobin structure: sickle cell anemia and related abnormalities
50. Methemoglobinemia and other dyshemoglobinemias
51. Fragmentation hemolytic anemia
52. Erythrocyte disorders as a result of chemical and physical agents
53. Hemolytic anemia due to infections with microorganisms
54. Immune Hemolytic Anemia
55. Alloimmune hemolytic disease of the fetus and newborn
56. Hypersplenism and hyposplenism
57. Primary and Secondary Polycythemias
58. The porphyrias
59. Hereditary and acquired (polyclonal) sideroblastic anemias
60. Structure and composition of neutrophils, eosinophils, and basophils
61. Production, distribution, and fate of neutrophils
62. Eosinophils and their disorders
63. Basophils and mast cells, and their disorders
64. Classification and clinical manifestations of neutrophil disorders
65. Neutropenia and neutrophilia
66. Disorders of neutrophil function
67. Structure, biochemistry, and function of monocytes and macrophages
68. Production, distribution, and fate of monocytes and macrophages
69. Classification and clinical manifestations of disorders of monocytes and macrophages
70. Monocytosis and monocytopenia
71. Inflammatory and malignant histiocytosis
72. Gaucher Disease and Related Lysosomal Storage Diseases
73. Structure, composition, and biochemistry of lymphocytes and plasma cells
74. Lymphopoiesis
75. Functions of B lymphocytes and plasma cells in immunoglobin production
76. Functions of T lymphocytes: T-cell receptors for antigen
77. Functions of natural killer cells
78. Classification and clinical manifestations of lymphocyte and plasma cell disorders
79. Lymphocytosis and lymphocytopenia
80. Immunodeficiency diseases
81. Hematological manifestations of acquired immunodeficiency syndrome (AIDS)
82. Mononucleosis syndromes
83. Classification and clinical manifestations of the clonal myeloid disorders
84. Polycythemia vera
85. Essential thrombocythemia
86. Primary myelofibrosis
87. Myelodysplastic disorders (Clonal cytopenias and oligoblastic leukemia)

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