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Since 1977, this outstanding book has been the immunology reference of choice for both veterinary students and practitioners. It""s the only complete resource on the subject, featuring a straightforward presentation of basic immunologic principles with comprehensive information on the most significant immunological diseases and responses seen in domestic animals. This meticulously updated new edition explores the latest advances in the field and provides a wealth of clinical examples that illustrate and clarify important concepts.

New to This Edition:
- Completely updated section on innate immunity includes new chapters on natural killer (NK) cells and systemic responses to infection to ensure you have the most up-to-date information.
- New information on genomics and molecular diagnostic techniques explores how the emerging field of genomics impacts disease resistance and immunology in general, as well as the diagnosis and treatment of immunological and infectious diseases.
- Updated content provides new information on well-recognized older diseases such as rheumatoid arthritis, systemic lupus, and inflammatory bowel disease, as well as current information on new diseases such as devil facial tumor disease and bovine neonatal pancytopenia.
- Expanded coverage brings you the latest knowledge on resistance to infection, such as vaccine usage, especially with respect to duration of immunity, the effects of key vitamins and lipids on immune responses, the effects of old age on immunity, and both antiviral and parasitic immunity.
- Diagnostic tests described throughout the text include a new section on the analysis of ELISA test data, as well as a brief summary of molecular diagnostic techniques.
- Coverage reflecting a significant change in the overall view of immunology provides you with the foundational knowledge needed to grasp the broad pattern of immunologic reactions and understand how the immune system functions as an interconnected network, rather than a series of independent pathways.
- New discussions of the critical importance of commensal bacteria and intestinal flora explain help you understand the importance of this normal flora with respect to antibacterial immunity, allergies, and autoimmunity, while at the same time providing a broader view of the animal body and its microflora as a "superorganism."
- A discussion of the importance of adipose tissue in immunity and inflammation addresses the epidemic of obesity in domestic pets and the extraordinary growth rates expected of domestic livestock.
- The section on inflammatory mechanisms has been divided into separate chapters focusing on the detection of invaders and the mediators of inflammation to incorporate the vast amount of new information on pattern recognition receptors and the ways in which they warn the body of microbial invasion.

1. Defense of the Body
2. Innate Immunity: The Recognition of Invaders
3. Innate Immunity: Proinflammatory and Antimicrobial Mediators
4. Innate Immunity: Neutrophils and Phagocytosis
5. Innate Immunity: Macrophages and Recovery from Inflammation
6. Systemic Responses to Inflammation
7. Innate Immunity: The Complement System
8. Cell Signaling: Cytokines and Their Receptors
9. Antigens: Triggers of Adaptive Immunity
10. Dendritic Cells and Antigen Processing
11. The Major Histocompatibility Complex
12. Organs of the Immune System
13. Lymphocytes
14. Helper T Cells and Their Response to Antigen
15. B Cells and Their Response to Antigen
16. Antibodies: Soluble Antigen Receptors
17. How Antigen-Binding Receptors are made
18. T-Cell Function and the Destruction of Cell-Associated Invaders
19. The Third Lymphocyte Population: Natural Killer Cells
20. Regulation of Adaptive Immunity
21. Immunity in the Fetus and Newborn
22. Immunity at Body Surfaces
23. Vaccines and Their Production
24. The Use of Vaccines
25. Immunity to Bacteria and Fungi
26. Immunity to Viruses
27. Immunity to Parasites
28. Type I Hypersensitivity
29. Red Cell Antigens and Type II Hypersensitivity
30. Immune Complexes and Type III Hypersensitivity
31. Type IV Hypersensitivity: Delayed Hypersensitivity
32. Organ Graft Rejection
33. Resistance to Tumors
34. Autoimmunity: General Principles
35. Organ-Specific Autoimmune Diseases
36. The Systemic Immunological Diseases
37. Primary Immunodeficiencies
38. Secondary Immunological Defects
39. Drugs and Other Agents That Affect the Immune System
40. The Evolution of the Immune System
41. Immunodiagnostic Techniques

Libreria Médica Berri 2022 ®