DESCRIPTION:
A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular research, but also offers vascular biologists and cardiologists a detailed how-to guide to the development of the many powerful new therapeutics now emerging.
CONTENTS:
PART I ACUTE MECHANICAL INJURY AND VASCULAR REPAIR
1 Mechanical Injury in Normal and Atherosclerotic Rabbit Iliac Arteries
2 The Porcine Model of Coronary Restenosis
3 Atherosclerotic Porcine Coronary Stent Model: Technical Methods for Preclinical Studies
4 Nonhuman Primate Models of Arterial Injury and Repair
5 Experimental Models of Arteriovenous Grafting
6 Wire Denudation and Ligation Models of the Mouse Carotid Artery
7 Endothelial Denudation and Arterial Dilation in the Mouse
8 Vascular Photochemical Injury in the Mouse
9 Mouse Model of Transluminal Femoral Artery Injury
PART II MODELS OF ARTERIAL THROMBOSIS
10 A Murine Model of Arterial Injury and Thrombosis
11 Folts Cyclic Flow Animal Model for Studying In Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls
PART III CHRONIC ATHEROSCLEROTIC MODELS
12 Mouse Models of Atherosclerosis
13 Rabbit Models of Atherosclerosis
14 Atherosclerosis in Nonhuman Primates
PART IV VASCULAR DISEASE IN TRANSPLANTED VESSELS
15 Murine Carotid Loop Model of Transplant Vascular Disease
16 Murine Heterotopic Model of Transplant Arteriopathy
17 Hyperacute Vascular Rejection: Lessons from Pig-to-Primate Xenotransplantation
PART V VASCULAR DISEASE IN MODELS OF ARTERIAL HYPERTENSION
18 Methods for Examining Cerebrovascular Disease
in Experimental Models of Hypertension
19 Monocrotaline-Induced Pulmonary Hypertension in Rats
20 Chronic Pulmonary Hypertension in the Hypoxic Rat and in the Sheep Following Continuous Air Embolization
PART VI ANIMAL CARE AND TISSUE PROCESSING
21 Veterinary Issues and Anesthesia Options
22 Histological and Immunohistochemical Methods for Vascular Animal Model Studies
