DESCRIPTION:
The newest edition of the essential guide to pancreatic medicine
The fourth edition of The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery integrates the cutting-edge research of recent years to update its presentation of this fast-growing subject. It details every known disorder of the pancreas, grounding them in a thorough understanding of pancreatic function, enhanced with high quality illustration and graphs. It also includes step-by-step guidance for relevant endoscopic techniques and surgical procedures.
The Pancreas readers will also find:
- New comprehensive insights into three pancreatic diseases: autoimmune pancreatitis, cystic neoplasms, and neuroendocrine tumors
- An editorial team with decades of clinical and research experience in the US, Europe, and Asia
- Over 500 downloadable illustrations for use in scientific presentations
The Pancreas is a foundational reference for clinicians and researchers in gastroenterology and gastrointestinal surgery.
CONTENTS:
Section 1 Anatomy of the Pancreas
1 Development of the Pancreas and Related Structures
2 Anatomy, Histology, and Fine Structure of the Pancreas
3 Congenital and Inherited Anomalies of the Pancreas
Section 2 Physiology and Pathophysiology of Pancreatic Functions
4 Physiology of Acinar Cell Secretion
5 Physiology of Duct Cell Secretion
6 Physiology and Pathophysiology of Function of Sphincter of Oddi
7 Neurohormonal and Hormonal Control of Pancreatic Secretion
8 Regulation of Pancreatic Protein Synthesis and Growth
9 Fibrogenesis in the Pancreas: The Role of Pancreatic Stellate Cells
10 Pancreatic Endocrine-Exocrine Relationship
Section 3 Acute Pancreatitis
11 Epidemiology and Etiology of Alcohol-Induced Pancreatitis
12 Epidemiology and Etiology of Biliary Acute Pancreatitis
13 Genetic Factors in Acute Pancreatitis
14 The Role of the Intestine and Mesenteric Lymph in the Development of Organ Dysfunction in Severe Acute Pancreatitis
15 The Role of Neurogenic Inflammation in Pancreatitis
16 Molecular, Biochemical, and Metabolic Abnormalities of Acute Pancreatitis
17 Histopathology of Acute Pancreatitis
18 Severity Classification of Acute Pancreatitis
19 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis
20 Acute Pancreatitis Associated with Congenital Anomalies
21 Acute Pancreatitis in Children
22 Acute Pancreatitis Associated with Metabolic, Infections, and Drug-Related Diseases
23 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis
24 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition
25 ICU Treatment of Severe Acute Pancreatitis
26 Clinical Course and Medical Treatment of Acute Pancreatitis_Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations
27 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis
28 Management of Infected Necrosis: Step-Up Approach
29 Management of Infected Pancreatic Necroses: An Endoscopic Approach
30 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis
31 Open Surgical Debridement of Necrotizing Pancreatitis: Late Postoperative Morbidity and Outcome
32 Endoscopic Treatment of Biliary Acute Pancreatitis
33 Strategies for the Treatment of Pancreatic Pseudocysts and Walled-Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches
34 Pseudocysts and Walled-Off Necrosis After Acute Pancreatitis: Surgical Approach
35 Management of Fluid Collection in Acute Pancreatitis
36 Management of Pancreatic Fistula in Acute Pancreatitis
37 Long-Term Outcome After Treatment of Acute Pancreatitis
Section 4 Chronic Pancreatitis
38 Definition and Classification of Chronic Pancreatitis
39 Molecular Understanding of Chronic Pancreatitis
40 Natural History of Recurrent Acute and Chronic Pancreatitis
41 Pediatric Recurrent Acute and Chronic Pancreatitis: Role of Pancreas Divisum
42 Clinical and Laboratory Diagnosis of Chronic Pancreatitis
43 Abdominal Imaging for the Diagnosis of Chronic Pancreatitis
44 Endoscopic Ultrasound for Diagnosis of Chronic Pancreatitis Versus Pancreatic Cancer
45 Hereditary Pancreatitis and Complex Genetic Causes
46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis
47 CFTR-Associated Pancreatic Disease
48 Alcohol and Smoking in Chronic Pancreatitis
49 Idiopathic and Rare Causes of Chronic Pancreatitis
50 Early Chronic Pancreatitis
51 Chronic Pancreatitis with Inflammatory Mass in the Pancreatic Head
52 Structural Complications: Strictures, Stones, Pseudocysts, and Vascular Complications
53 Nutritional Evaluation and Support: An Overview
54 Exocrine Pancreatic Insufficiency
55 Bone Disease in Chronic Pancreatitis
56 Diabetes from Exocrine Pancreatic Disease
57 Oxidative Stress and Antioxidants in Chronic Pancreatitis
58 Pain Mechanisms in Chronic Pancreatitis
59 Pain Management in Chronic Pancreatitis
60 Adjunctive Therapy in Chronic Pancreatitis
61 Pancreatic Cancer Risks in Chronic Pancreatitis
62 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and Pseudocysts
63 Major Pancreatic Resection for Chronic Pancreatitis: Indication, Goals, and Limitations
64 Pancreatic Drainage Procedures: Techniques and Results
65 Duodenum-Preserving Pancreatic Head Resections for Chronic Pancreatitis: Techniques and Results
66 Total Pancreatectomy with Islet Autotransplantation
67 Minimally Invasive Surgical Management of Chronic Pancreatitis
Section 5 Autoimmune Pancreatitis
68 Epidemiology of Autoimmune Pancreatitis
69 Molecular Immunology and Pathogenesis of Autoimmune Pancreatitis
70 Clinical Manifestation of Type 1 Autoimmune Pancreatitis
71 Clinical Manifestation of Type 2 Autoimmune Pancreatitis
72 Clinical Diagnostic Criteria for Autoimmune Pancreatitis
73 Laboratory Diagnosis of Autoimmune Pancreatitis
74 What Is the Evidence Measuring Immune Markers
75 Autoimmune Pancreatitis and IgG4-Related Disease
76 Imaging Diagnosis of Autoimmune Pancreatitis
77 Medical Management of Autoimmune Pancreatitis
78 Management of Intractable Autoimmune Pancreatitis
79 Long-Term Outcome After Treatment of Autoimmune Pancreatitis
Section 6 Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas
80 Epidemiology of Cystic Neoplasms of the Pancreas
81 Histologic Classification and Staging of Cystic Neoplasm
82 Molecular Mechanisms of Cystic Neoplasia
83 Clinical Presentation of Pancreatic Cystic Neoplasms
84 Evaluation of Cystic Lesions Using EUS, MRI, and CT
85 Cytologic Evaluation of Cystic Neoplasm: The Role of Liquid Biopsy
86 Natural History of Cystic Neoplasm: IPMN, MCN, SCN, and SPN
87 Surveillance or Surgical Treatment in Asymptomatic Cystic Neoplasm
88 Artificial Intelligence in the Detection and Surveillance of Cystic Neoplasms
89 Oncologic Resection of IPMN and MCN: Open Approach_Results
90 Surgical Treatment of Cystic Neoplasms: Laparoscopic and Robotic Approach_Results
91 Robotic-Assisted Resection of Cystic Neoplasms
92 Duodenum-Preserving Pancreatic Head Resection for Cystic Neoplasms of the Pancreatic Head: Indication and Limitations
93 Pancreatic Middle Segment Resection of Cystic Neoplasms: Indications and Limitations
94 Tumor Enucleation for Cystic Neoplasms of the Pancreas: Indications and Limitations
95 Duodenum-Preserving Pancreatic Head Resection and Local Extirpation of SPTP in Children and Adolescents: Indication and Long-Term Results
96 Management of Recurrence of Cystic Neoplasms
97 Long-Term Outcome After Observation and Surgical Treatment of Cystic Neoplasm: What Is the Evidence?
Section 7 Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas
98 Epidemiology and Classification of Neuroendocrine Tumors of the Pancreas
99 Pathology of Neuroendocrine Neoplasms
100 Molecular Genetics of Neuroendocrine Tumors
101 What Is the Origin of Pancreatic Endocrine Tumors?
102 Clinical Manifestation of Endocrine Tumors of the Pancreas
103 Evidence of Hormonal, Laboratory, Biochemical, and Instrumental Diagnostics of Neuroendocrine Tumors of the Pancreas
104 Pancreatic Neuroendocrine Tumors in Multiple Neoplasia Syndromes
105 Non-Functioning Pancreatic Neuroendocrine Neoplasm: Diagnosis and Management Principles
106 Medical and Nucleotide Treatment of Neuroendocrine Tumors of the Pancreas
107 Interventional Radiology in the Treatment of Pancreatic Neuroendocrine Tumors
108 Enucleation of Benign, Neuroendocrine Tumors of the Pancreas
109 Duodenum-Preserving Pancreatic Head Resection or Local Extirpation of Neuroendocrine Tumors of the Pancreas Larger than 2 cm
110 Individualized Surgery for Nonfunctional Pancreatic Neuroendocrine Tumors (NF-pNET) <2 cm: Indication, Surgical Principles, and Long-Term Outcome
111 Surgical Treatment of Endocrine Tumors: Major Oncologic Resection
112 The Management of Insulinoma
113 Evidence of Medical and Surgical Treatment of Gastrinoma
114 Rare Neuroendocrine Tumors of Pancreas: Management and Evidence of Surgical Treatment
115 Treatment of Neuroendocrine Neoplasia of the Pancreas and Biliary Tract
116 Survival After Treatment of Endocrine Tumors
Section 8 Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer
117 Epidemiology of Pancreatic Cancer
118 Smoking, a Risk for Pancreatic Cancer: Experimental and Clinical Data
119 Molecular Understanding of Development of Ductal Pancreatic Cancer
120 From Tissue Turnover to the Cell of Origin of Pancreatic Cancer
121 Microbiome of Pancreatic Cancer: Involvement in Cancer Development and Chemo-/Immunotherapy
122 Molecular Subtypes and Clinical Applications
123 Tumor Microenvironment: Immune Cells and Immunosuppressive Functions of Carcinoma-Associated Fibroblasts and Macrophages
124 Familial Pancreatic Cancer
125 Pathology of Exocrine Pancreatic Tumors
126 Pancreatic Cancer: Precancerous Lesions
127 Clinical History and Risk Factors of Pancreatic Cancer
128 The Role of Endoscopic Ultrasonography in the Diagnosis and Differential Diagnosis of Neoplastic Lesions
129 Radiologic Diagnosis of Pancreatic Cancer: CT, MRI
130 Screening of Hereditary Pancreatic Cancer
131 The Role of PET in Diagnosis of Pancreatic Cancer and Cancer Recurrence
132 Tumor Markers in Pancreatic Malignancies
133 The Role of Laparoscopy and Peritoneal Cytology in the Management of Pancreatic Cancer
134 Clinical Assessment and Staging of Advanced Pancreatic Cancer
135 Pancreatic Cancer: Indications for Resection
136 Pancreatoduodenectomy for Pancreatic Cancer, Short and Long-Term Outcome After Kausch-Whipple and Pylorus-Preserving Pancreatoduodenectomy
137 Left Pancreatectomy for Body and Tail Cancer
138 Total Pancreatectomy: Indication and Limitations
139 Minimally Invasive Resection for Pancreatic Cancer
140 Robotic Resection for Pancreatic Cancer
141 Extended Radical Surgery for Pancreatic Cancer
142 Palliative Pancreatic Resection: Is it Justified?
143 Outcome of Patients after R0 Resection for Locally Advanced Pancreatic Cancer - Combined with Hepatic Metastasectomy: Indication and Limitations
144 Bypass Surgery for Advanced Pancreatic Cancer
145 Endoscopic and Interventional Palliation of Pancreatic Cancer
146 Neoadjuvant Treatment of Pancreatic Cancer: Evidence for Treatment Effect
147 Locally Advanced Pancreatic Cancer: Does the Addition of Stereotactic Body Radiation Therapy to Neoadjuvant Chemotherapy Lead to a Significant Survival Improvement after R0 Resection?
148 Adjuvant Chemotherapy in Pancreatic Cancer: First-Line and Second-Line Treatment_Benefits of Survival
149 Role of Radiation Therapy for Pancreatic Cancer
150 Immunotherapy for Pancreatic Cancer: Check-Point Blockade and Vaccine Therapy
151 Targeted Therapies for Pancreatic Cancer
152 Precision Cancer Medicine
153 Palliative Chemotherapy for Advanced Pancreatic Cancer: Treatment Modalities, Side Effects, and Benefits of Survival
154 Management of Pain in Pancreatic Cancer
155 Management of Cancer Recurrence
156 Survival and Late Morbidity after Resection of Pancreatic Cancer
Section 9 Periampullary Cancers and Tumors Other Than Pancreatic Cancer
157 Periampullary Tumors: Clinical Presentation and Diagnostic Strategies
158 Histology and Genetics of Cancer of the Papilla, Distal Common Bile Duct, and Duodenum
159 Adenoma and Adenocarcinoma of the Ampulla of Vater: Diagnosis and Management
160 Endoscopic Treatment of Adenomas of the Ampulla of Vater: Techniques, Results, Benefits, and Limitations
161 Surgical Treatment of Papillary and Ampullary Tumors: Management and Long-Term Results
162 Surgical Treatment of Duodenal Cancer
163 Surgical Treatment of Distal Cholangiocarcinoma
164 Adjuvant and Palliative Chemotherapy of Periampullary Cancers
165 Long-Term Survival after Resection of Periampullary Cancer
Section 10 Transplantation of the Pancreas
166 Transplantation of Pancreatic Islets
167 Transplantation of the Pancreas