DESCRIPTION:
Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.
CONTENTS:
Part I: Role of Translation Factors
1. Regulation of Protein Synthesis by eIF4E in the Brain
2. Translational Control Through the eIF4E Binding Proteins in the Brain
3. The Integrated Stress Response in Memory and Cognitive Disorders
4. The Role of the Eukaryotic Elongation Factor 2 (eEF2) Pathway in Neuronal Function
5. Sidekick No More: Neural Translation Control by p70 ribosomal S6 kinase 1
Part II: Role of Specific Elements in the mRNA
6. Dendritic Targeting and Regulatory RNA Control of Local Neuronal Translation
7. Internal Ribosome Entry Site-Mediated Translation in Neuronal Protein Synthesis
8. RNA Modifications in the Central Nervous System
9. Role of CPEB-Family Proteins in Memory
10. FMRP and MicroRNAs in Neuronal Protein Synthesis
11. Focusing on mRNA Granules and Stalled Polysomes Amidst Diverse Mechanisms Underlying mRNA Transport, mRNA Storage and Local Translation
Part III: Physiological Roles of Translation
12. Protein Synthesis and Synapse Specificity in Functional Plasticity
13. Regulation of Synaptic Homeostasis by Translational Mechanisms
14. Multiple Roles of RNA Regulatory Factors in Neuronal Development and Function in C. elegans
15. Regulation of mRNA Translation in Axons
16. Protein Synthesis and Translational Control in Neural Stem Cell Development and Neurogenesis
Part IV: Neuronal Protein Synthesis and Disease
17. Translational Controls in Pain
18. Dysregulated Translation in Autism Spectrum Disorder
19. Neuronal mRNA Translation in Addiction
20. Dysregulated Protein Synthesis in Major Depression Disorder
21. Dysregulation of Neuronal Protein Synthesis in Alzheimer""s Disease
22. RNA-Binding Proteins and Translation in Neurodegenerative Disease
23. Role of Eukaryotic Initiation Factor eIF2B in Vanishing White Matter Disease
