DESCRIPTION:
Whenever the heart is challenged with an increased workload for a prolonged period, it responds by increasing its muscle mass - a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situations such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss) and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy.
The Hypertrophied Heart compiles state-of-the-art presentations in the area of molecular biology, cellular physiology and signal transduction in cardiac hypertrophy and heart failure to help in the formulation of new concepts and approaches for stimulating research. The book contains two sections: Mechanisms of Cardiac Hypertrophy, and Cardiac Failure in the Hypertrophied Heart. It is hoped that both students and scientists, as well as clinical and experimental cardiologists, will find this book useful in understanding the molecular and cellular events underlying the development of cardiac hypertrophy and the transition from cardiac hypertrophy to heart failure.
CONTENTS:
A: Mechanisms of Cardiac Hypertrophy.
1. Signal Transduction in Adapted Heart: Implication of Protein Kinase C-Dependent and -Independent Pathways J. Debarros, D.K. Das. 2. Glucose-6-Phosphate Dehydrogenase: A Marker of Cardiac Hypertrophy H.-G. Zimmer. 3. Regulation of Ribosomal DNA Transcription During Cardiomyocyte Hypertrophy T. Arino, et al. 4. Mitochondrial Gene Expression in Hypertrophic Cardiac Muscles in Rats T. Murakami, et al. 5. Serca2 and ANF Promoter-Activity Studies in Hypertrophic Cardiomyocytes using Liposome-, Gene Gun- and Adenovirus-Mediated Gene Transfer K. Eizema, et al. 6. Ca2+ Transients, Contractility and Inotropic Responses in Rabbit Volume-Overload Cardiomyocytes K. Sakurai, et al. 7. Responsiveness of Contractile Elements to Muscle Length Change in Hyperthyroid Ferret Myocardium T. Ishikawa, et al. 8. Contraction-Dependent Hypertrophy of Neonatal Rat Ventricular Myocytes: Potential Role for Focal Adhesion Kinase D.M. Eble, et al. 9. Molecular Mechanism of Mechanical Stress-Induced Cardiac Hypertrophy I. Komuro. 10. Possible Roles of the Tenascin Family During Heart Development and Myocardial Tissue Remodeling K. Imanaka-Yoshida, et al. 11. Cardiac Cell-ECM Interactions: A Possible Site for Mechanical Signaling S. Kanekar, et al. 12. Integrin-Dependent and -Independent Signaling During Pressure Overload Cardiac Hypertrophy M. Laser, et al. 13. Role of G-Proteins in Hypertension and Hypertrophy M. Anand-Srivastava, F. di Fusco. 14. Three-Dimensional Nuclear Size and DNA Content in Hypertensive Heart Disease A. Takeda, et al. 15. Age-Related Anisotropic Changes in Cardiocyte Connections in Spontaneously Hypertensive Rats M. Okabe, et al. 16. Stimulation of Mitogen-Activated Protein Kinases ERK 1 and ERK 2 by H2O2 in Vascular Smooth Muscle Cells A.K. Srivastava, S.K. Pandey. 17. Effects of Renin-Angiotensin System Inhibition on Cardiac Hypertrophy and Fibrosis in Spontaneously Hypertensive Rats N. Makino, et al. 18. Adaptation of the Poikilothermic Heart to Catecholamine-Induced Overload B. Ostadal, et al. 19. Angiogenesis and Fibrosis During Right Ventricular Hypertrophy in Human Tetralogy of Fallot H.S. Sharma, et al. 20. Molecular Mechanisms of Phenotypic Modulation of Vascular Smooth Muscle Cells M. Kurabayashi, R. Nagai.
B: Cardiac Failure in Hypertrophied Heart.
21. Protein Kinase C Activation in Cardiac Hypertrophy and Failure Y. Takeishi, et al. 22. Angiotensin II and Connective Tissue Homeostasis K.T. Weber. 23. Beneficial Effects of Angiotensin Blockade in Heart Failure due to Myocardial Infarction N.S. Dhalla, X. Guo. 24. Activated TGF-&bgr Signaling in Heart After Myocardial Infarction J. Hao, et al. 25. gp 130 Dependent Signaling Pathways: Recent Advances and Implications for Cardiovascular Disease K. Yamauchi-Takihara, et al. 26. Molecular Genetic Aspects of Hypertrophic Cardiomyopathy in the Oriental A. Kimura. 27. Hepatitis C Virus Infection in Hypertrophic or Dilated Cardiomyopathy A. Matsumori. 28. Enhancement of Early Diastolic Filling Provoked by Dobutamine Infusion in Dilated Cardiomyopathy S. Kurokawa, et al. 29. DNA Fragmentation is a Possible Mechanism for Heart Failure in Cardiomyopathy Y. Sawa, et al. 30. The Difference of Phosphorylation of Desmin and Myosin Light Chain 2 in the Bio 14.6 Cardiomyopathic Heart T. Hayakawa, et al. 31. Cardiac Remodeling in Cardiomyopathic Hamster Hearts H. Kawaguchi. 32. Human Myocardial Na,K-ATPase in Remodeling K. Kjeldsen. 33. Nitric Oxide Synthase Gene Transfer Inhibits Protein Synthesis of Rat Cardiac Mycocytes U. Ikeda, et al. 34. Human Heart Failure: A Mechanistic Assessment of Altered Ventricular Function N.R. Alpert, L.A. Mulieri. 35. The Structural Correlate of Reduced Cardiac Function in Failing Human Hearts S. Kostin. 36. Diastolic Dysfunction and Diastolic Heart Failure K. Yamamoto, et al. 37. Effects of Melatonin on Cardiac Function and Metabolism in the Ischemic Working Rat Heart K.-I. Masui, et al.
