DESCRIPTION:
Richly illustrated with figures and examples and supplemented with a glossary of terms, The Evolutionary Roots of Human Brain Diseases assembles recent findings in clinical neuroscience, evolutionary biology, anthropology, and cellular biology to elucidate the origins of human brain diseases and how evolution has given rise to exclusive impacts on brain health only in humans. The book is succinct, up-to-date, and written by researchers across numerous disciplines, making it a compulsory read for clinical neurologists, psychologists, and all medical researchers interested in the brain.
The book""s 22 chapters cover basic science concepts behind cerebral cellular specificities or human-specific network developments, detailed discussions of neurological or psychiatric diseases and their clinical expression with an evolutionary focus, the newest imaging techniques to study the brain, future medication developments, as well as cultural and societal repercussions. Evolutionary concepts ranging from genetic pleiotropic antagonism to disease remnants of ancient behaviours crucial for survival are also presented. Insightful and innovative in its approach, this book offers a fascinating interdisciplinary dialogue on the potential repercussions of ongoing human brain evolution.
CONTENTS:
Part I: Human Brain Evolution: From Anatomy to Function
Chapter 1: Human Telencephalization
Chapter 2: Evolutionary Aspects of Glial Expansion
Chapter 3: The Contribution of Mitochondrial Evolution and Dysfunction to Neurodegeneration
Chapter 4: Intrinsic Templates for Neurodegenerations Featuring Disease-specific Axonal or Dendritic Vulnerability
Chapter 5: Differences in Brain Gene Expression Between Humans and Primates
Chapter 6: Adapative Archaic Introgression
Chapter 7: Goal-directed and Habitual Behaviors: Anatomical and Functional Circuits in Health and Neurological Disease
Part II: How Human Brain Diseases Are Impacted By Human Evolution
Chapter 8: Alzheimer""s Disease, the Parietal Lobes, and the Evolution of the Human Genus
Chapter 9: Parkinson""s Disease - Overstrain Focused of Basal Ganglia and Brainstem Nuclei
Chapter 10: Brain Diseases Associated with Unstable Repeats
Chapter 11: The Properties of Cortico-Motoneuronal Connections and Their Evolutionary Significance for Amyotrophic Lateral Sclerosis
Chapter 12: REM Sleep Behavior Disorder - Nocturnal Replay of a "Fight and Flee"
Chapter 13: Mood Disorders: An Evolutionary Psycho-Neuro-Immunological Approach
Chapter 14: Schizophrenia - Embracing the Spectrum
Chapter 15: Williams Syndrome and Autism - Dysfunction of Frontal Networks
Chapter 16: ADHD - An Evolutionary View
Chapter 17: Addiction - Diverted Reward and Motivation Principles
Part 3: Consequences and perspectives on research and clinical sciences
Chapter 18: Conditions of Comparative Brain Connectomics
Chapter 19: Are Evolutionary Concepts Helfpul in Designing Preventive Strategies for Brain Diseases?
Chapter 20: Evolutionary Aspects of Neuro-Psychopharmocology
Chapter 21: Ongoing Human Evolution?
Chapter 22: Human Cultural Evolution Outpaces Biological Evolution: A Brain Connectomic Approach
Chapter 23: Concluding Remarks and Future Directions
