DESCRIPTION:
This highly illustrated textbook has been prepared by the Working Group on Development, Anatomy and Pathology of the European Society of Cardiology (ESC). The ESC Textbook of Cardiovascular Development is the authority on cardiovascular development from a perspective of both basic scientists and clinicians.
The embryonic origin of congenital heart diseases and their pathology has been analysed in depth. Modern concepts pivotal to the understanding of cardiovascular morphogenesis, including those still subject to controversy, have been highlighted and the content covers the ESC Core Curriculum.
The textbook will appeal to researchers and clinicians from a wide spectrum of disciplines including molecular and developmental biologists working on mechanisms of heart development in a range of model organisms as well as pathologists, morphologists, geneticists, and cardiologists.
CONTENTS:
1: Relevance of developmental studies for clinicians
Section 1: Origin, distribution and determination of cardiovascular cell progenitors
2: An evolutionary perspective on the origin of the cardiovascular system of vertebrates
3: From epiblast to mesoderm: elaboration of a fate map for cardiovascular progenitors
4: Cardiac Fields and myocardial cell lineages
5: Origin and diversity of embryonic endothelium/endocardium
6: Transcriptional regulation of early cardiovascular development
Section 2: Molecular regulation of cardiac tissue differentiation and patterning
7: Incorporation of myocardial progenitors to the arterial pole of the heart
8: The Developmental Origin of Myocardium at the Venous Pole of the Heart
9: Cardiac growth (I): Cardiomyocyte proliferation
10: Cardiac growth (I): Cardiomyocyte polarisation
11: Defining cardiac domains from the inside: NOTCH in endocardial-myocardial interactions
12: Origin and diversity of cardiac fibroblasts: developmental substrates of adult cardiac fibrosis
Section 3: Morphogenesis of cardiovascular structures. On form and function
13: Building the cardiovascular system: the acquisition of a functional form
14: Cardiac looping and laterality
15: Origin and development of the cardiac conduction system
16: Blood vessel differentiation and growth
17: From cushions to leaflets: Morphogenesis of cardiac atrioventricular valves
18: Development of the arterial valves
19: The role of neural crest in cardiac development
20: The multiple functions of the proepicardial/epicardial cell lineage in heart development
21: The development of coronary vascularization
Section 4: Abnormal cardiac morphogenesis and the origin of congenital heart disease
22: The genetics of congenital heart disease
23: Development of the Outflow Tract
24: Arterial wall remodelling in congenital heart disease
25: Coronary anomalies
26: Myocardial non-compaction
27: Developmental Aspects of Cardiac Arrhythmias
Section 5: Frontiers in cardiovascular development
28: Advanced therapies to treat cardiovascular diseases. Controversies and perspectives
29: The zebrafish as a model for cardiac development and regenerationPerivascular adipose tissue and metabolic syndrome
30: Cells to repair the infarcted myocardium
31: The role of non-coding RNA/micro RNAs in cardiac disease
32: Egigenetics and post-transcriptional regulation of cardiovascular development
33: Complex network interactions: cardiovascular system biology
Authors:
Edited by José M. Pérez-Pomares, Department of Animal Biology, Faculty of Sciences , University of Malaga, and Robert Kelly, Aix-Marseille Université, Developmental Biology Institute of Marseilles
José M. Pérez-Pomares obtained his PhD in Biological Sciences at the University of Málaga in 2000, and was post-doctoral fellow at the Department of Anatomy and Cell Biology, Medical University of South Carolina until 2002. He is now a professor at the Deparment of Animal Biology at the University of Malage and is the chair of Nucleus (board) of the Working Group on Development, Anatomy and Pathology of the European Society of Cardiology. As PI of the Cardiovascular Development & Disease (DeCA) research group, Dr. Pérez-Pomares is interested in the developmental bases of cardiovascular disease, and the team aims at identifying new diagnostic and prognostic markers as well as therapeutical targets and advanced therapies to treat the diseased heart. He is author of 10 book chapters and more than 60 publications in peer-reviewed, international journals.
