DESCRIPTION:
A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and complete descriptions of the most up-to-date views on the diagnosis and treatment of the disease. The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.
CONTENTS:
PART I: BASIC PATHOPHYSIOLOGY AND BIOCHEMISTRY OF DIABETIC NEPHROPATHY
A. Pathophysiology
1. Angiotensin II and Its Receptors in the Pathogenesis of Diabetic Nephropathy
2. Altered Renal Microvascular Function in Early Diabetes
B. Interstitial Disease
3. Proteinuria and Interstitial Fibrogenesis in Diabetic Nephropathy
C. Podocytes
4. Podocytes and Diabetic Nephropathy
D. Altered Metabolic Pathways
5. Altered Glucose Transport and Its Metabolic Effects in Glomerular Cells
6. mRNA Translation in Diabetic Nephropathy
7. The Hexosamine Biosynthesis Pathway: Contribution to the Pathogenesis of Diabetic Nephropathy
E. Nonenzymatic Glycosylation
8. Glycation: Receptor for Advanced Glycation Endproducts and Diabetic Nephropathy
F. Oxidative Stress
9. Oxidative and Glycooxidative Stress in Diabetic Nephropathy
G. Growth Factors
10. Connective Tissue Growth Factor in the Pathogenesis of Diabetic Nephropathy: A Target for Therapeutic Intervention
11. Vascular Endothelial Growth Factor as a Determinant of Diabetic Nephropathy
12. Transforming Growth Factor-â Signal Transduction in the Pathogenesis of Diabetic Nephropathy: Identifying Molecular Targets for Therapeutic Intervention
H. New Approaches to the Study of Diabetic Nephropathy
13. Hepatocyte Growth Factor: Physiological and Therapeutic Ligand to Attenuate Diabetic Nephropathy
14. Proteomics in the Investigation of Diabetic Nephropathy
15. Gene Expression Profiling in the Investigation of Diabetic Nephropathy
16. PPAR-ã Ligands and Diabetic Nephropathy
17. á-Endosulfine in Diabetic Nephropathy
18. The Prospect of a Novel Therapeutic, Bone Morphogenetic Protein-7, in Diabetic Nephropathy
PART II: CLINICAL ASPECTS OF DIABETIC NEPHROPATHY
A. Genetics and Risks
19. Genetic Determinants of Diabetic Nephropathy in Type 2 Diabetes
20. Major Risk Indicators for Diabetic Kidney Disease
B. Histopathology and Special Populations
21. The Structure of Human Diabetic Nephropathy
22. Diabetic Kidney Disease in Transitional and Disadvantaged Populations
C. Diagnosis and Treatment
23. Screening and Treatment of Early Diabetic Renal Disease in Type 1 and Type 2 Diabetes
24. Treatment in Advanced Renal Disease in Type 1 and Type 2 Diabetes
25. Diabetic and Renal Disease: ACE Inhibitors and/or Angiotensin Receptor Blockers: Does It Matter?
26. Management of Diabetic End-Stage Renal Disease With Dialysis
D. Related Abnormalities
27. Diabetic Retinopathy and Nephropathy
28. Hypertension and Cardiovascular Disease
29. Endothelial Dysfunction and Diabetic Nephropathy
30. Anemia and Diabetic Nephropathy
