DESCRIPTION:
This is the first handbook on the whole field of stem cell research covering (1) molecular and cellular fundamentals, (2) clinical applications and (3) GMP processing. It provides a timely overview of the potential and plasticity of adult stem cells. With its focus on standardization and quality control of cell lines suited for processing and clinical trials, the book features novel therapeutic approaches that offer great promise for new ways of treating neural, hematological and cardiovascular diseases.
The editors are leading international experts in adult stem cell research, and their successful networking in the US and Europe has resulted in a distinguished team of authors from around the world.
CONTENTS:
Part I Stem Cell Biology.
1. Clinical Potentials of Stem Cells: Hype or Hope?
2. Alteration of Hematopoietic Stem Cell Fates by Chromatin-Modifying Agents
3. Increasing Impact of Micro RNAs in Stem Cell Biology and Medicine
Part II Standardization and Quality Assurance of Stem Cell Preparations.
4. Novel Strategies for the Mobilization of Hematopoietic Stem Cells
5. Pluripotent Stem Cells from Umbilical Cord Blood
6. Good Manufacturing Practices: Clinical-Scale Production of Mesenchymal Stem Cells
7. The Clonal Activity of Marked Hematopoietic Stem Cells
Part III On the Threshold to Clinical Applications.
8. ALarge Animal Non-Injury Model for Study of Human Stem Cell Plasticity
9. Developmental Potential of Somatic Stem Cells Following Injection into Murine Blastocysts
10. Testing the Limits: The Potential of MAPC in Animal Models
11. Mesenchymal Stem Cells as Vehicles for Genetic Targeting of Tumors
Part IV Clinical Trials.
12. Endothelial Progenitor Cells for Cardiac Regeneration
13. Stem Cells and Bypass Grafting for Myocardial and Vascular Regeneration
14. Adoptive Immunotherapy: Guidelines and Clinical Practice
15. Immune Escape and Suppression by Human Mesenchymal Stem Cells
16. Stem Cell Transplantation: The Basis for Successful Cellular Immunotherapy
