DESCRIPTION:
Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact.
This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.
CONTENTS:
Preface
Part I Methodologies
1. Tools to study signaling
Part II Normal Signaling Processes
2. Cell-cycle Signaling, Epigenetic and Nuclear Function
3. Signaling in the Endothelium
4. Rapid Signaling Pathways
5. Growth Factors Signaling Pathways
6. Ion Channels Signaling
7. Lipids Signaling
Part III Mitochondria
8. Heart Mitochondria: A Receiver and Integrator of Signals
Part IV Pediatric Cardiology
9. Signaling Pathways in Cardiovascular Development
10. Signaling in Congenital Heart Disease
Part V Aging
11. Signaling in the Aging Heart
Part VI Signaling in Cardiovascular Disease
12. Signaling in Endomyocarditis
13. Signaling Pathways in Hypertension
14. Gene Expression and Signaling Pathways in Myocardial Ischemia
15. Signaling in Hypertrophy and Heart Failure
16. Signaling in Diabetes and Metabolic Syndrome
17. Dysrhythmias/Channelopathies and Signaling Pathways
18. Signaling in Atherosclerosis
Part VII Targeting Signaling in Cardiovascular Medicine
19. Stem Cells Signaling Pathways
20. Cardioprotection and Signaling Pathways
21. Targeting Specific Pathways
Part VIII Looking to the Future
22. Future Frontiers in Cardiovascular Signaling.
Glossary
