DESCRIPTION:
Renal Cell Carcinoma: Clinical Management provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in kidney cancer. The volume reviews new data about risk factors for the disease, profiles the new staging system for renal cell carcinoma (RCC), highlights our current understanding of familial syndromes of RCC and their molecular genetics, and provides new perspectives about imaging of renal tumors. For localized disease, a greater appreciation of nephron-sparing approaches and the importance of preservation of renal function is discussed in detail. Advances in surgical techniques are highlighted. For metastatic disease, the molecular biology of kidney cancer is reviewed in a concise and understandable manner, including the data that has fostered novel targeted approaches that have revolutionized management. The several landmark phase III targeted therapy trials published in the last few years are placed in context with respect to current management.
CONTENTS:
Section I: Localized Disease
1. Etiology of RCC: Incidence, Demographics, and Environmental Factors
2. Pathology of Renal Cell Carcinoma
3. Familial Renal Cell Carinoma
4. Imaging of Renal Cell Carcinoma
5. Prognostic Factors for Localized Renal Cell Carcinoma
Section II: Management of Localized RCC
6. Assessment of Oncologic Risk for Clinical Stage T1 Renal Tumors and the Emerging Role of Renal Mass BiopsyBy
7. Radical Nephrectomy for Localized Renal Tumors: Oncological and Renal Functional Considerations
8. Nephron-Sparing Surgery for Renal Cancer
9. Thermal Ablation
10. Active Surveillance of the Small Renal Mass
Section III: Locally Advanced Disease
11. Locally Advanced Renal Cell Carcinoma
12. Neoadjuvant Targeted Therapy and Consolidative Surgery
Section IV: Advanced Disease
13. Biology of RCC (VEGF, mTOR, immune aspects)
14. Prognostic Factors in Advanced Renal Cell Carcinoma
15. Integration of Surgery in Metastatic Renal Cancer
16. Immunotherapy for Renal Cell Carcinoma
17. Targeted Therapy: Vascular Endothelial Growth Factor (VEGF)
18. mTOR in Renal cell carcinoma
19. Palliative and Supportive Care for Renal Cancer
