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Offering today""s most authoritative, comprehensive coverage of sleep disorders, Kryger""s Principles and Practice of Sleep Medicine, 7th Edition, is a must-have resource for sleep medicine specialists, fellows, trainees, and technicians, as well as pulmonologists, neurologists, and other clinicians who see patients with sleep-related issues. It provides a solid understanding of underlying basic science as well as complete coverage of emerging advances in management and treatment for a widely diverse patient population. Evidence-based content, hundreds of full-color illustrations, and a wealth of additional resources online help you make well-informed clinical decisions and offer your patients the best possible care.

Contains new chapters on sleep in intersex and transgender individuals sleep telemedicine and remote PAP adherence monitoring and sleep and the menstrual cycle, as well as increased coverage of treatment and management of pediatric patients.

Includes expanded sections on pharmacology, sleep in individuals with other medical disorders, and methodology. Discusses updated treatments for sleep apnea and advancements in CPAP therapy.

Offers access to 95 video clips online, including expert interviews and sleep study footage of various sleep disorders. Meets the needs of practicing clinicians as well as those preparing for the sleep medicine fellowship examination or recertification exams, with more than 950 self-assessment questions, answers, and rationales online. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

1 History of Sleep Physiology and Medicine
2 Normal Human Sleep: An Overview
3 Normal Aging
4 Daytime Sleepiness and Alertness
5 Sleep Deprivation
6 Introduction/Defining sleep
7 Neural Control of Sleep in Mammals
8 REM Sleep control and function
9 Deep-Brain Imaging of Brain Neurons and Glia during Sleep
10 Evolution of mammalian sleep
11 Sleep in Non-mammalian Vertebrates
12 Introduction: Genetics and Genomics of Sleep
13 Genetics and Genomics of Circadian Clocks
14 Genetics and Genomic Basis of Sleep in Simple Model Organisms
15 Genetics and Genomic Basis of Sleep in Rodents
16 Genetics and Genomic Basis of Sleep in Healthy Humans
17 Genetics and Genomic Basis of Sleep Disorders in Humans
18 Introduction to Physiology in Sleep
19 What Neuroimaging Reveals About the Brain Areas Generating, Maintaining and Regulating Sleep
20 Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation
21 Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders
22 Respiratory Physiology: Central Neural Control of Respiratory Neurons and Motoneurons during Sleep
23 Respiratory Physiology: Understanding the Control of Ventilation
24 Physiology of the Upper and Lower Airways
25 Respiratory Physiology: Sleep at High Altitudes
26 Sleep and Host Defense
27 Endocrine Physiology in Relation to Sleep and Sleep Disturbances
28 Thermoregulation in Sleep and Hibernation
29 Memory Processing in Relation to Sleep
30 Sensory and Motor Processing during Sleep and Wakefulness
31 Local and Use Dependent Aspects of Sleep
32 Pathophysiology of Sleep-Wake Disturbances after Traumatic Brain Injury
33 Introduction
34 Master Circadian Clock and Master Circadian Rhythm
35 Anatomy of the Mammalian Circadian System
36 Physiology of the Mammalian Circadian System
37 Human Circadian Timing System and Sleep-Wake Regulation
38 Sleep Homeostasis and Models of Sleep Regulation
39 Circadian Rhythms in Sleepiness, Alertness, and Performance
40 Central and Peripheral Circadian Clocks
41 Circadian Dysregulation and Cardiometabolic and Immune Health
42 Circadian Dysregulation in Brain Aging and Neuropsychiatric Health
43 Circadian Disorders of the Sleep-Wake Cycle
44 Introduction
45 Adenosine
46 Role of catecholamines in sleep-wake control in health and disease
47 Cholinergics
48 Histamine
49 Hypocretin/orexin
50 Serotonin and sleep
51 Melatonin
52 Opioids
53 Drugs That Disturb Sleep and Wakefulness
54 Introduction
55 Why We Dream
56 Dream Content: Quantitative Findings
57 EEG Correlates of Sucessful Dream Recall
58 The Neurobiology of Dreaming
59 Lucid Dreaming
60 What is the Function of Nightmares?
61 Dreams and Nightmares in Posttraumatic Stress Disorder
62 Incorporation of Waking Experiences into Dreams
63 Emotion, Motivation, and Reward in Relation to Dreaming
64 Dreaming during Pregnancy
65 Approach to the Patient with Disordered Sleep
66 Cardinal Manifestations of Sleep Disorders
67 Physical Examination of the Sleep Medicine Patient
68 Use of Clinical Tools and Tests in Sleep Medicine
69 Classification of Sleep Disorders
70 Epidemiology of Sleep Disorders
71 Sleep Medicine, Public Policy, and Public Health
72 Introduction
73 Sleep Forensics: Criminal Culpability for Sleep-Related Violence
74 Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them
75 Legal Aspects of Fatigue- and Safety-Sensitive Professions
76 Sleep Medicine Clinical Practice and Compliance - United States
77 Sleep Medicine Clinical Practice and Compliance - Europe
78 Introduction
79 Performance Deficits During Sleep Loss and Their Operational Consequences
80 Sleep and Sleep Disorders in Operational Settings
81 Shift Work, Shift-Work Disorder, Jet Lag, and Jet lag Disorder
82 Fatigue Countermeasures
83 Sleep, Sleepiness, and Performance Prediction Modeling
84 Fatigue Risk Management Systems
85 Safety Cases and Assessing Alternative Means of Regulatory Compliance in Fatigue Risk Management
86 Fatigue Proofing
87 Sleep and Athletic Performance
88 Assessment of the Occupational Sleep Medicine Field
89 Advances in Insomnia Pathophysiology and Treatment: An Introduction
90 Insomnia: Epidemiology, Risk Factors, & Health Disparities
91 Etiology and Pathophysiology of Insomnia
92 Pediatric Insomnia and its Developmental Trajectories
93 Insomnia Diagnosis, Assessment and Evaluation
94 Insomnia with Short Sleep Duration and Multidimensional Sleep Health
95 Behavioral Treatment I - Therapeutic Approaches and Implementation
96 Behavioral Treatment II - Efficacy, Effectiveness and Dissemination
97 Behavioral Treatment III - Digital and Telehealth Approaches
98 Pharmacological Treatment I - Therapeutic Approaches and Implementation
99 Pharmacological Treatment II - Efficacy, Effectiveness and Contraindications
101 Introduction
102 Parkinsonism
103 Sleep-Wake Disturbances and Stroke
104 Sleep and Neuromuscular Diseases
105 Alzheimer Disease and Other Dementias
106 Epilepsy
107 Sleep and Headache
108 Sleep Disorders after Traumatic Brain Injury
109 Autoimmune disorders (autoimmune encephalitides and MS)
110 Central Disorders of Hypersomnolence
111 Narcolepsy: Pathophysiology and Genetic Predisposition
112 Narcolepsy: Diagnosis and Management
113 Idiopathic Hypersomnia
114 Kleine-Levin Syndrome
115 Parasomnias-Overview and Approach
116 Disorders of Arousal
117 Sleep-Related Eating Disorder
118 REM Sleep Behavior Disorder
119 Nightmares and Dream Disturbances
120 Other Parasomnias
121 Restless Legs Syndrome and Periodic Limb Movements During Sleep
122 Movement Disorders in Sleep (other than PLMS)
123 Introduction
124 Central Sleep Apnea: Definitions, Pathophysiology, Genetics, and Epidemiology
125 Central Sleep Apnea: Diagnosis and Management
126 Anatomy and Physiology of Upper Airway Obstruction
127 Snoring and Pathologic Upper Airway Resistance Syndromes
128 Obstructive Sleep Apnea: Heritable Phenotypes and Genetics
129 Deep Phenotyping Across Diagnostic and Therapeutic Continuum of OSA
130 Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea
131 Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management
132 Positive Airway Pressure Treatment for Obstructive Sleep Apnea
133 Pharmacological Treatments for Sleep Apnea Syndromes
134 Alternative strategies to management of Sleep Disordered Breathing
135 Brain Health in Sleep Apnea
136 Obstructive Sleep Apnea and Metabolic Disorders
137 Overlap Syndromes of Sleep and Breathing Disorders
138 Obesity-Hypoventilation Syndrome
139 Obstructive Sleep Apnea, Obesity, and Bariatric Surgery
140 Advanced modes of positive pressure therapy for sleep-disordered breathing
141 Sleep and Breathing at High Altitude
142 Evolution of sleep disordered breathing across the adult years
143 Introduction
144 Sleep-Related Cardiac Risk
145 Cardiac Arrythmogenesis During Sleep: Mechanisms, Diagnosis, and Therapy
146 Cardiovascular Effects of Sleep-Related Breathing Disorders
147 Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea
148 Coronary Artery Disease and Obstructive Sleep Apnea
149 Heart Failure
150 Stroke/TIA and SDB
151 Insomnia and CVD
152 Introduction
153 Sleep and Cancer across the Lifespan
154 Fibromyalgia and Chronic Fatigue Syndromes
155 Endocrine Disorders
156 Pain and Sleep
157 Sleep in Chronic Kidney Disease
158 Sleep in the Critically Ill Patient
159 Peri-operative Sleep Medicine
160 Sleep and GI
160 Sleep in Chronic Respiratory Failure
161 Introduction
162 Stress and Sleep
162 Emotion and Sleep
163 Anxiety Disorders
164 Mood Disorders
165 Schizophrenia and Sleep
166 Substance Abuse
167 Dentistry and Otorhinolaryngology in Sleep Medicine: below the brain and above the larynx
168 Oronasopharyngeal growth & Skeletal Malformations
169 Sleep Bruxism: Definition, Prevalence, Etiology and Mechanisms
170 Sleep Bruxism: Diagnostic Considerations
171 Management of sleep bruxism: psychological, dental, and medical approaches in adults
172 Orofacial Pain/TMD in Relation to Sleep Bruxsim and Breathing Disorders
173 Oral Appliances for Sleep-Disordered Breathing
174 Anesthesia in Upper Airway Surgery
175 Upper airway surgery to treat SBD
176 Pharmacotherapy, Complementary, and Alternative Medicine for Sleep Bruxism
177 Overview
179 Neuromuscular disorders: Muscular Dystrophy, Spinal Muscular Atrophy, Mitochondrial Disorders, Myasthenia Gravis, Spina Bifida/Chiari Malformation, Cerebral Palsy, Myotonic Dystrophy, Seizure Disorders
180 Transitional Care for Adolescents with Narcolepsy and other central disorders of hypersomnolence
181 Congenital Heart Disease
183 Introduction
184 Sex Effects and Differences in Circadian Rhythms and Sleep
184 Syndromes Associated with Developmental Delays: Down syndrome, Marfan""s syndrome, Other
185 The Menstrual Cycle, Sleep and Circadian Rhythms
186 Sleep and Sleep Disorders Associated with Pregnancy
187 Sleep Disordered Breathing during Pregnancy
188 Postpartum Period and Early Parenthood
189 Sleep and Menopause
190 Introduction
191 Psychiatric and Medical Comorbidities and Effects of Medications in Older Adults
192 Introduction
192 Obstructive Sleep Apnea in Older Adults
193 Insomnia in Older Adults
194 Circadian Rhythms in Older Adults
195 Sleep in Long-Term Care Settings
196 Section Introduction: Polysomnography and beyond
197 Sleep stage scoring
198 CNS Arousals & Cyclic Alternating Patterns
199 Neurologic Monitoring Techniques
200 Monitoring Techniques for Evaluating Suspected Sleep-Disordered Breathing
201 Sleep Telemedicine and Remote PAP Adherence Monitoring
202 Cardiopulmonary Coupling
203 Pulse Wave Analysis
204 Recording and Scoring Sleep-related Movements
205 Home Sleep Testing for Sleep Related Breathing Disorders
206 Consumer sleep tracking: ANSI/CTA performance standards
206 Consumer Sleep
207 Evaluating Sleepiness and Fatigue
209 Surveys, Sampling, and Polling Methods for Sleep and Public Health
210 Techniques for Clinical Assessment of Circadian Rhythm Disorders
211 Actigraphy Methods and Technical Issues
212 Imaging
213 Sleep and Covid

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