DESCRIPTION:
This substantially revised second edition contains new chapters on the role of GPIIb/IIIa blockade during acute coronary syndromes or with fibrinolytic therapy during acute myocardial infarctions, and updated and expanded information on the latest trials of GP IIb/IIIa inhibition during percutaneous coronary intervention. Additional improvements include a new chapter on outcomes with chronic oral GP IIb/IIIa blockade following acute coronary syndromes, discussion of GPIIb/IIIa blockade with other platelet and thrombin inhibitors, and a review of the potential effects beyond inhibition of platelet aggregation. Platelet Glycoprotein IIb/IIIa inhibitors in Cardiovascular Disease, Second Edition offers today""s physicians, cardiologists, emergency room doctors, and basic scientists the most complete and authoritative review of the state-of-the-art in glycoprotein Iib/IIIa receptor inhibitor use.
CONTENTS:
PART I BASIC PRINCIPLES
1 Thrombosis in Acute Coronary Syndromes and Coronary Interventions
2 Platelet Adhesion
3 Glycoprotein IIb/IIIa in Platelet Aggregation and Acute Arterial Thrombosis
4 Glycoprotein IIb/IIIa Antagonists: Development of Abciximab and Pharmacology of Abciximab, Tirofiban, and Eptifibatide
PART II GLYCOPROTEIN IIB/IIIA BLOCKADE DURING CORONARY INTERVENTION
5 Abciximab During Percutaneous Coronary Intervention: EPIC, EPILOG, and EPISTENT Trials
6 Eptifibatide in Coronary Intervention: The IMPACT and ESPRIT Trials
7 Tirofiban in Interventional Cardiology: The RESTORE and TARGET Trials
8 Overview of the Glycoprotein IIb/IIIa Interventional Trials
PART III GLYCOPROTEIN IIB/IIIA BLOCKADE FOR ACUTE ISCHEMIC SYNDROMES
9 The Use of Abciximab in Therapy-Resistant Unstable Angina: Clinical and Angiographic Results of the CAPTURE Pilot Trial and the CAPTURE Study
10 Unstable Angina Trials: PARAGON, PURSUIT, PRISM, PRISM-PLUS, and GUSTO-IV
11 Platelet Glycoprotein IIb/IIIa Inhibitors and an Invasive Strategy
12 Glycoprotein IIb/IIIa Receptor Blockade in Myocardial Infarction: Adjunctive Therapy to Percutaneous Coronary Interventions
13 Glycoprotein IIb/IIIa Receptor Blockade in Acute Myocardial Infarction: Adjunctive Therapy to Fibrinolysis
PART IV PRACTICAL ISSUES AND FUTURE APPLICATIONS
14 Economics of Glycoprotein IIb/IIIa Inhibition
15 Platelet Monitoring and Interaction of Glycoprotein IIb/IIIa Antagonists with Other Antiplatelet Agents
16 Platelet Glycoprotein IIb/IIIa Antagonists: Their Interaction with Low-Molecular-Weight Heparins and Direct Thrombin Inhibitors
17 Oral Agents
18 Platelet Glycoprotein IIb/IIIa Inhibitors: Effects Beyond the Platelet
19 Cerebrovascular Interventions
20 Cerebrovascular Aspects of Glycoprotein IIb/IIIa Receptor Inhibitors
21 Evolution of Drug Development in Evidence-Based Medicine: Summary and the Future
