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This brand new textbook of rheumatoid arthritis (RA) is an important addition to the Oxford Textbooks in Rheumatology series, and provides a comprehensive overview of both the scientific and clinical aspects of the disease. Divided into eight sections - from the history, diagnosis, and epidemiology of the disease, through the pathogenesis, clinical presentation, and assessment to treatments and management strategies, both drug- and non-drug based - each chapter is written by leading clinicians and scientists in the field to deliver a contemporary view of RA.

During the past two decades there have been revolutionary changes in the understanding and management of rheumatoid arthritis, in particular the development of biological treatments. This has had wide-ranging effects on almost all aspects of treatment, from effectiveness and intensity to the nature and the cost. Providing a comprehensive account of the modern ideas about the disease, the Oxford Textbook of Rheumatoid Arthritis is a key new addition to the literature, with each chapter providing a detailed background, key recent advances, and areas of doubt and future developments.

Featuring over 170 photographs, radiological images, and clinical charts to aid both diagnosis and illustrate the rationale behind key scientific studies, this new title will prove an indispensable resource for specialist rheumatologists, trainees in rheumatology, and other members of the multi-disciplinary team.

1. History, diagnosis, and epidemiology
1: The history of rheumatoid arthritis
2: Diagnosis
3: The descriptive epidemiology of rheumatoid arthritis
4: Modifiable and other risk factors for rheumatoid arthritis: a basis for prevention and better therapy
2. Pathogenesis
5: Genetics and epigenetics of rheumatoid arthritis
6: Dysregulation of synovial fibroblasts in rheumatoid arthritis
7: Autoantibodies in rheumatoid arthritis
8: Dendritic cells and T cells in rheumatoid arthritis
9: Mechanisms of bone and cartilage destruction
10: Cytokines and other mediators
3. Clinical presentation
11: Clinical features of rheumatoid arthritis
12: Pre-rheumatoid arthritis
13: Non-articular manifestations of rheumatoid arthritis
14: Comorbidity in rheumatoid arthritis
4. Disease assessment
15: Disease activity assessment in rheumatoid arthritis
16: Synovial biopsies
17: Radiography in rheumatoid arthritis
18: Ultrasound in rheumatoid arthritis
19: MRI in rheumatoid arthritis
5. Impact on life
20: Patient physical function in rheumatoid arthritis
21: Fatigue
22: Health economics
23: Rheumatoid arthritis and work
6. Non-drug treatments
24: Exercise
25: Foot health
26: Occupational therapy
27: Self-management: a patient""s perspective
7. Drug treatments
28: Analgesics, Opioids, and NSAIDs
29: Glucocorticoids
30: Conventional disease modifying drugs
31: Tumour necrosis factor inhibitors
32: Interleukin-6 inhibitors
33: B-cell therapies
34: Biosimilars
35: Immunogenicity in response to biologic agents
36: The use of JAK inhibitors in the treatment of rheumatoid arthritis
37: Combination therapy in rheumatoid arthritis
38: Translation of new therapies: from bench to bedside
39: Adverse events in clinical studies in rheumatoid arthritis
8. Management and outcomes
40: Prevention of rheumatoid arthritis
41: Treatment targets and remission
42: Clinical outcomes
43: Clinical guidelines
44: European biologics registers
45: Voluntary patient registries

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