DESCRIPTION:
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters.
Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye. Ocular Transporters in Ophthalmic Diseases and Drug Delivery is the first text book in this field and offers up-to-date information to clinicians, research scientists in academia, and the pharmaceutical industry. This work has clinical implications for drug development and therapeutic drug delivery, making it an invaluable resource for readers.
CONTENTS:
I. Transport in the Anterior Segment
1. Aquaporins and Water Transport in the Cornea
2. Roles of Corneal Epithelial Ion Transport Mechanisms in Mediating Responses to Cytokines and Osmotic Stress
3. Vitamin C Transport, Delivery, and Function in the Anterior Segment of the Eye
II. Transporters of the Ciliary Epithelium
4. Mechanisms of Aqueous Humor Formation: Cellular Model of Aqueous Inflow
III. Lens Transporters
5. Membrane Transporters: New Roles in Lens Cataract
6. Lens Na+, K+-ATPase
IV. Transport Across the Blood-Retinal Barrier
7. Pathophysiology of Pericyte-containing Retinal Microvessels: Roles of Ion Channels and Transporters
8. Molecular Mechanisms of the Inner Blood-Retinal Barrier Transporters
V. Transport Across the Retinal Pigment Epithelium
9. Regulation of Transport in the RPE
10. Glucose Transporters in Retinal Pigment Epithelium Development
11. Ca2+ Channels in the Retinal Pigment Epithelium: Modulators of Retinal Pigment Epithelium Function and Communication with Neighboring Tissues
12. Taurine Transport Pathways in the Outer Retina in Relation to Aging and Disease
13. P-Glycoprotein Expression and Function in the Retinal Pigment Epithelium
VI. Transporters in the Retina
14. The Retinal Rod NCKX1 and Cone/Ganglion Cell NCKX2 Na+/Ca2+-K+ Exchangers
15. Excitatory Amino Acid Transporters in the Retina
16. Localization and Function of Gamma Aminobutyric Acid Transporter 1 in the Retina
VII. Genetic Variants of Ocular Transporters: Implication in Drug Metabolism and Eye Diseases
17. Biochemical Defects Associated with Genetic Mutations in the Retina-Specific ABC Transporter, ABCR, and Macular Degenerative Diseases
18. Glutamate Transporters and Retinal Disease and Regulation
19. Glutamate Transport in Retinal Glial Cells during Diabetes
VIII. Ocular Drug Delivery
20. The Emerging Significance of Drug Transporters and Metabolizing Enzymes to Ophthalmic Drug Design
21. Barriers in Ocular Drug Delivery
22. Ophthalmic Applications of Nanotechnology
23. Vitamin C Transporters in the Retina
24. The Plasma Membrane Transporters and Channels of Corneal Endothelium
