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Nunn""s Applied Respiratory Physiology Ninth Edition is your concise one-stop guide to all aspects of respiratory physiology in health disease and in the many physiologically challenging situations and environments into which humans take themselves - coverage is from basic science to clinical applications.

Trusted for over 50 years this most comprehensive single volume on respiratory physiology will prove invaluable to those in training or preparing for examinations in anaesthesia intensive care respiratory medicine or thoracic surgery - as well as an essential quick reference for physiologists and the range of practitioners requiring ready access to current knowledge in this field.

Now fully revised and updated this ninth edition includes a larger page format for improved clarity as well as full access to the complete downloadable eBook version. This incorporates BONUS chapters handy topic summaries interactive self-assessment material and a NEW series of expert lectures on key topics. The result is a more flexible engaging and complete resource than ever before.

Enhancements to this edition include:
- A new dedicated chapter on obesity - covering the effects of this global challenge on the physiology of the respiratory system in health and disease in both adults and children
- Expanded coverage of the adverse effects of hyperoxia - including the physiology of the now popular technique of high-flow nasal therapy
- A revised section on air pollution - reflecting the growing importance and understanding of the impact of pollution on the lungs and other body systems along with the latest worldwide guidelines
- Detailed coverage of artificial ventilation during general anaesthesia - covering post-operative respiratory complications and the physiological basis of current best-practice for optimizing ventilation
- Print comes with enhanced eBook - includes access to the complete fully searchable text PLUS:
bonus chapters
handy chapter summaries
interactive self-assessment material
a NEW series of 25 expert lectures focusing on the most essential topics in respiratory physiology

Part 1: Basic Principles
1. Functional anatomy of the respiratory tract
Mouth, nose and pharynx
The larynx
The tracheobronchial tree
The alveoli
Alveolar cell types
The pulmonary vasculature
Chapter 1 summary_functional anatomy of the respiratory tract
2. Elastic forces and lung volumes
Elastic recoil of the lungs
Elastic recoil of the thoracic cage
Pressure-volume relationships of the lung plus thoracic cage
Static lung volumes
Principles of measurement of compliance
Principles of measurement of static lung volumes
Chapter 2 summary_elastic forces and lung volumes
3. Respiratory system resistance
Physical principles of gas flow and resistance
Respiratory system resistance
Factors affecting respiratory resistance
Muscular control of airway diameter
Drug effects on airway smooth muscle
Compensation for increased resistance to breathing
Principles of measurement of respiratory resistance and closing capacity
Chapter 3 summary_respiratory system resistance
4. Control of breathing
The origin of the respiratory rhythm
Central nervous system connections to the respiratory centre
Peripheral input to the respiratory centre and nonchemical reflexes
The influence of carbon dioxide on respiratory control
The influence of oxygen on respiratory control
Periodic breathing
Breath holding
Drug effects on the control of breathing
Methods for assessment of breathing control
Chapter 4 summary_control of breathing
5. Pulmonary ventilation
Upper airway muscles
Respiratory muscles of the trunk
Integration of respiratory muscle activity
Neuronal control of respiratory muscles
Respiratory muscle fatigue and disuse
The work of breathing
Measurement of ventilation
Measurement of ventilatory capacity
Assessment of the respiratory muscles
Chapter 5 summary_pulmonary ventilation
6. The pulmonary circulation
Pulmonary blood flow
Pulmonary blood volume
Pulmonary vascular pressures
Pulmonary vascular resistance
Passive changes in pulmonary vascular resistance
Active control of pulmonary vascular resistance
Drug effects on the pulmonary circulation
Principles of measurement of the pulmonary circulation
Chapter 6 summary_the pulmonary circulation
7. Distribution of pulmonary ventilation and perfusion
Distribution of ventilation
Distribution of perfusion
Ventilation in relation to perfusion
Dead space
Venous admixture or shunt
The effect of scatter of ratios on arterial Po2
Principles of assessment of distribution of ventilation and pulmonary blood flow
Chapter 7 summary_distribution of pulmonary ventilation and perfusion
8. Diffusion of respiratory gases
Fundamentals of the diffusion process
Diffusion of oxygen in the lungs
Diffusion of carbon dioxide in the lungs
Diffusion of carbon monoxide in the lungs
Factors affecting diffusing capacity
Diffusion of oxygen in the tissues
Principles of measurement of diffusing capacity
Chapter 8 summary_diffusion of respiratory gases
9. Carbon dioxide
Carriage of carbon dioxide in blood
Factors influencing the Pco2 in the steady state
Carbon dioxide stores and the unsteady state
Carbon dioxide carriage during hypothermia
Outline of methods of measurement of carbon dioxide
Chapter 9 summary_carbon dioxide
10. Oxygen
Oxygen cascade
Carriage of oxygen in the blood
Role of oxygen in the cell
Transport of oxygen from the lungs to the cell
Oxygen stores
Measurement of oxygen consumption and delivery
Chapter 10 summary_oxygen
11. Nonrespiratory functions of the lung
Defence against inhaled substances
Chemical hazards
Processing of endogenous compounds by the pulmonary vasculature
Pharmacokinetics and the lung
The endocrine lung
Chapter 11 summary_nonrespiratory functions of the lung
Part 2: Applied Physiology
12. Pregnancy, neonates and children
Respiratory function in pregnancy
The lungs before birth
Events at birth
Neonatal lung function
Premature birth and the lungs
Sudden infant death syndrome
Development of lung function during childhood
Chapter 12 summary_pregnancy, neonates and children
13. Exercise
Oxygen consumption during exercise
Anaerobic metabolism
Ventilatory response to exercise
Fitness and training
Chapter 13 summary_exercise
14. Sleep
Normal sleep
Sleep-disordered breathing
Chapter 14 summary_sleep
15. Obesity
Respiratory physiology of obesity
Impact of obesity on lung disease
Obesity hypoventilation syndrome
Chapter 15 summary_obesity
16. High altitude and flying
Respiratory system responses to altitude
Altitude illness
Chapter 16 summary_high altitude and flying
17. High pressure and diving
Exchange of oxygen and carbon dioxide
Effects attributable to the composition of the inspired gas
Types of diving activity and their respiratory effects
Respiratory aspects of decompression illness
Chapter 17 summary_high pressure and diving
18. Respiration in closed environments and space
Closed-system anaesthesia
Chapter 18 summary_respiration in closed environments and space
19. Drowning
Physiology of immersion
Physiological mechanisms of drowning
The role of hypothermia
Principles of therapy for near-drowning
Chapter 19 summary_drowning
20. Smoking and air pollution
Tobacco smoke
Mechanisms of smoking-related lung damage
Air pollution
Chapter 20 summary_smoking and air pollution
21. Anaesthesia
Control of breathing
Pattern of contraction of respiratory muscles
Change in functional residual capacity
Atelectasis during anaesthesia
Respiratory mechanics
Gas exchange
Other effects of general anaesthesia on the respiratory system
Anaesthesia in specific patient groups
Special circumstances relevant during anaesthesia
Regional anaesthesia
Respiratory function in the postoperative period
Chapter 21 Summary_anaesthesia
22. Changes in the carbon dioxide partial pressure
Causes of hypocapnia
Causes of hypercapnia
Effects of carbon dioxide on the nervous system
Effects on other body systems
Hypercapnia in clinical practice
Chapter 22 Summary_changes in the carbon dioxide partial pressure
23. Hypoxia
Biochemical changes in hypoxia
Mechanisms of hypoxic cell damage
Po2 level at which hypoxia occurs
Effects of hypoxia
Chapter 23 Summary_hypoxia
24. Anaemia
Pulmonary function
Oxygen delivery
Anaemia and exercise
Anaemia in the clinical setting?
Chapter 24 Summary_anaemia
25. Oxygen toxicity and hyperoxia
Oxygen toxicity
Defences against reactive oxygen species
Normobaric hyperoxia
Clinical effects of normobaric hyperoxia
Hyperbaric hyperoxia
Chapter 25 Summary_oxygen toxicity and hyperoxia
26. Comparative respiratory physiology
Designs of respiratory system
Respiratory systems of major phyla
Carriage of gases in blood
Animals at physiological extremes
Pathophysiology of animal respiratory diseases in veterinary practice
Chapter 26 Summary_comparative respiratory physiology
Part 3: Physiology of Pulmonary Disease
27. Ventilatory failure
Pattern of changes in arterial blood gases
Causes of ventilatory failure
Relationship between ventilatory capacity and ventilatory failure
Principles of therapy for ventilatory failure
Chapter 27 Summary_ventilatory failure
28. Airways disease
Chronic obstructive pulmonary disease
Cystic fibrosis
Chapter 28 Summary_airways disease
29. Pulmonary vascular disease
Pulmonary oedema
Pulmonary embolism
Pulmonary hypertension
Hepatopulmonary syndrome
Chapter 29 Summary_pulmonary vascular disease
30. Diseases of the lung parenchyma and pleura
Pulmonary collapse
Pulmonary consolidation (pneumonia)
Interstitial lung disease and pulmonary fibrosis
Lung cancer
Pleural disease
Chapter 30 Summary_diseases of the lung parenchyma and pleura
31. Acute lung injury
Clinical aspects of acute lung injury
Mechanisms of acute lung injury
Principles of therapy
Chapter 31 summary_acute lung injury
32. Respiratory support and artificial ventilation
Respiratory physiotherapy
Noninvasive ventilation
Intermittent positive pressure ventilation
Clinical use of intermittent positive pressure ventilation
Positive end-expiratory pressure
Physiological effects of positive pressure ventilation
Ventilator-induced lung injury
Artificial ventilation for resuscitation
Extrapulmonary gas exchange
Chapter 32 summary_respiratory support and artificial ventilation
33. Pulmonary surgery
Physiological aspects of common interventions
One-lung ventilation
Lung transplantation
Chapter 33 summary_pulmonary surgery
Online Content
34. The atmosphere
Evolution of the atmosphere
The greenhouse effect
Turnover rates of atmospheric gases
Oxygen, ozone and ultraviolet screening
Evolution and adaptation
35. The history of respiratory physiology
Ancient civilizations
The renaissance
Experimental physiology in the 17th century
Chemistry and respiration
Early development of current ideas of respiratory physiology
Appendix A: Physical quantities and units of measurement
Appendix B: The gas laws
Appendix C: Conversion factors for gas volumes
Appendix D: Symbols and abbreviations
Appendix E: Mathematical functions relevant to respiratory physiology

Author Information:
By Andrew B. Lumb, MB, BS, FRCA, Consultant Anaesthetist, St James"" University Hospital Honorary Clinical Associate Professor in Anaesthesia, University of Leeds, Leeds, UK. and Caroline R Thomas

Libreria Médica Berri 2022 ®