DESCRIPTION:
This volume illustrates the current lines of investigation of the angiogenic mechanisms based on contribution of circulating progenitor cells. The main themes that currently dominate this research field are: the origin of these cells, their tissue engraftment, their phenotypic modulation leading to the transformation into endothelial cells, etc. This volume is a key reference for angiogenesis researchers and students alike, in the fields of cardiovascular medicine, neoplastic disorders, wound management and tissue engineering, among others.
Key Features:
-Fresh data and concepts are presented to advance our understanding of basic angiogenic mechanisms.
- Focuses entirely on an emerging paradigm able to supplement the old angiogenic mechanism, called the "sprouting" model, in accounting for all real-life situations.
- Deals with the potential of progenitor cells to contribute to the maintenance and/or regeneration of tissues in an adult organism.
CONTENTS:
Introduction: Current Priorities in the Research of Circulating Pre-Endothelial Cells N.I. Moldovan.
1. In Vivo and in Vitro Properties of CD34+ And CD14+ Endothelial Cell Precursors G.C. Schatteman, O. Awad.
2. Evidence from a Leukemia Model for Maintenance of Vascular Endothelium by Bone-Marrow-Derived Endothelial Cells E. Gunsilius.
3. Cross Talk between Haematopoiesis and Angiogenesis D. Ribatti, A. Vacca, B. Nico, E. Crivellato, G. de Falco, M. Presta.
4. The Contribution of Adult Haematopoietic Stem Cells to Retinal Neovascularization M.B. Grant, S. Caballero, G.A.J. Brown, S.M. Guthrie, R.N. Mames, T. Vaught, E.W. Scott.
5. In Vitro Transformation of Monocytex and Dendritic Cells into Endothelial Like Cells K. Havemann, B.F. Pujol, J. Adamkiewicz.
6. Phenotypic Overlap between Monocytex and Vascular Endothelial Cells A. Schmeisser, C. Graffy, W.G. Daniel, R.H. Strasser.
7. Dissection of Monocyte and Endothelial Activities by Using VEGF-Receptor Specific Ligands M. Clauss, F. Pipp, K. Issbrücker, H. Weich, M. Heil, W. Schaper.
8. Circulating Endothelial Cells as a Novel Marker of Angiogenesis P. Mancuso, A. Calleri, C. Cassi, A. Gobbi, M. Capillo, G. Pruneri, G. Martinelli, F. Bertolini.
9. Tissular Insemination of Progenitor Endothelial Cells: The Problem and a Suggested Solution N.I. Moldovan.
