DESCRIPTION:
Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today""s clinical or experimental research.
CONTENTS:
PART I BIOLOGY OF NITRIC OXIDE
1 The Biological Chemistry of Nitric Oxide
2 Cell and Molecular Biology of Nitric Oxide Synthases
3 Cellular Signal Transduction and Nitric Oxide
4 Regulation of Gene Expression by Nitric Oxide
5 Cytotoxicity, Apoptosis, and Nitric Oxide
6 Nitric Oxide and Ion Channels
7 Role of Nitric Oxide in Vasomotor Regulation
8 Nitric Oxide and Platelet-Mediated Hemostasis
9 Nitric Oxide Modulates Leukocyte-Endothelial Cell Adhesion
10 Nitric Oxide and Cardiomyocyte Function
11 The Fibroblast and Nitric Oxide
12 Nitric Oxide in Cardiac Electrophysiology
PART II CARDIOVASCULAR PATHOPHYSIOLOGY OF NITRIC OXIDE
13 Nitric Oxide and Endothelial Dysfunction
14 Nitric Oxide and Hypertension
15 Nitric Oxide and Pulmonary Hypertension
16 Nitric Oxide in Atherosclerosis
17 Thrombotic Disorders and Nitric Oxide Insufficiency
18 Myocardial Nitric Oxide in Heart Failure
19 Shock States and Nitric Oxide
20 Stroke and Nitric Oxide
21 The Role of Nitric Oxide in Ischemia-Reperfusion
PART III NITRIC OXIDE IN CARDIOVASCULAR THERAPEUTICS
22 Nitrovasodilators
23 S-Nitrosothiols
24 Diazeniumdiolates (Formerly NONOates) in Cardiovascular Research and Potential Clinical Applications
25 Inhaled Nitric Oxide Therapy for Acute Respiratory Failure
26 Antioxidants and Endothelium-Derived Nitric Oxide Action
27 Coating Arterial and Blood-Contacting Surfaces with NO-Donating Compounds
28 Gene Therapy and Nitric Oxide
29 Nitric Oxide and Tissue Preservation in Transplantation
30 L-Arginine: Its Role in Cardiovascular Therapy
