DESCRIPTION:
- Extensively outlines latest bench research in spinal cord injury
- Discusses spinal cord neuroprotective and novel regenerative techniques
- Includes advances in the clinical setting
Neuroprotection and Regeneration of the Spinal Cord comprehensively covers the most recent research in the field of spinal cord injury. The first part of this book focuses on the latest animal models and clinically oriented work, providing extensive information on morphological factors and, biomechanical analysis, in addition to the mechanism of functional recovery. The book goes on to provide information on clinical relevance introducing analysis of spinal cord injuries using MRI and PET. Edited by renowned experts in the field, this book will provide clinical physicians, basic researchers, and postgraduate students with valuable insight into the cutting-edge research and progress in the field of spinal cord injury, treatment, and repair.
CONTENTS:
Part I Pathologies of spinal cord injury
1. The mechanism behind functional recovery after the incomplete spinal cord injury
2. Microenvironment within the injured spinal cord focusing on IL-6
3. Autophagy in spinal cord injury: pathogenic roles and therapeutic implications: autophagy
4. The role of the endoplasmic reticulum stress response in neural apoptosis of the injured spinal cord
5. Roles of microglia in spinal cord injury
Part II Pathologies of chronic compressive spinal cord
6. Biomechanics of the spinal cord and the pia mater
7. Biomechanical analysis of compressive myelopathy: the influence of morthometry of the spinal cord
8. Morphologic change and glial response to unilateral spinal cord compression
9. Morphological changes in anterior horn cells, immunoreactivity to neurotrophic factors and neuronal cell death of spinal cord lesions in the spinal hyperostotic mouse (twy/twy) with chronic mechanical cord compression
10. In vivo tracing of neural tracts in tip-toe walking Yoshimura mice by diffusion tensor tractography
11. Microarray analysis of expression of cell death-associated genes in spinal cord cells with cyclic tensile strain
12. Spinal Kyphosis causes Demyelination and Neuronal Loss in the Spinal Cord
Part III Neuroprotection
13. Granulocyte Colony-Stimulating Factor (G-CSF)-mediated neuroprotective therapy for spinal cord injury
14. Recombinant human hepatocyte growth factor promotes functional recovery after spinal cord injury
15. The proteoglycan-degrading enzymes promote functional recovery after spinal cord injury: Keratan sulfate and Chondroitin sulfate
16. Targeted retrograde gene delivery into the injured spinal cord using recombinant adenovirus vector carrying neurotrophic factor gene
17. Blockade of interleukin-6 effects on cytokines profiles and macrophage activation after spinal cord injury in mice
18. Oxidative stress as secondary injury mechanism after mechanical trauma in the spinal cord
Part IV Transplantation
19. Regenerative medicine for spinal cord injury utilizing iPS cells
20. Transplantation of neural stem cells with valproate for spinal cord injury
21. The effects of mesenchymal stem cell transduced multineurotrophin to improve function following spinal cord injury
22. Axonal regeneration across an artificial scaffold combined with cell transplantation applied to the transected spinal cord
23. Transplantation of mesenchymal stem cells derived from bone marrow in the injured spinal cord
24. Vascular regeneration therapies for spinal cord injury
Part V Clinical Relevance
25. Stress distribution of the spinal cord and clinical relevance in cervical spondylotic myelopathy
26. Applications and limitations of pNF-H, a novel biomarker for spinal cord injury
27. Neuroprotective therapy using granulocyte colony-stimulating factor (G-CSF) for acute spinal cord injury: a multicenter prospective controlled clinical trial
28. Assesment of injured spinal cord using diffusion tensor tractography
29. Clinical significance of 3D-MRI/18F-FDG PET fusion imaging of patients with cervical compressive myelopathy
30. Visualization of electrophysiological activity in the spinal cord using magnetospinography
31. Spinal synaptic plasticity in chronic pain
32. Evaluation of pain with functional neuroimaging
