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Neurons are arguably the most complex of all cells. From the action of these cells comes movement, thought and consciousness. It is a challenging task to understand what molecules direct the various diverse aspects of their function. This has produced an ever-increasing amount of molecular information about neurons, and only in Molecular Biology of the Neuron can a large part of this information be found in one source. In this book, a non-specialist can learn about the molecules that control information flow in the brain or the progress of brain disease in an approachable format, while the expert has access to a wealth of detailed information from a wide range of topics impacting on his or her field of endeavour. The text is designed to achieve a balance of accessibility and broad coverage with up-to-date molecular detail.

In the six years since the first edition of Molecular Biology of the Neuron there has been an explosion in the molecular information about neurons that has been discovered, and this information is incorporated into this second edition. Entirely new chapters have been introduced where recent advances have made a new aspect of neuronal function more comprehensible at the molecular level. Written by leading researchers in the field, the book provides an essential overview of the molecular structure and function of neurons, and will be an invaluable tool to students and researchers alike.

1. Studying neuronal function using the Drosophila genetic system
2. Using mouse genetics to study neuronal development and function
3. Gene expression: from precursor to mature neuron
4. Protein trafficking in neurons
5. Ion channels and electrical activity
6. Molecular biology of neurotransmitter release
7. Molecular biology of postsynaptic structures
8. Signal reception: Ligand-gated ion channel receptors
9. Signal reception: G protein-coupled receptors
10. Synapse-to-nucleus calcium signalling
11. Signalling by tyrosine phosphorylation in the nervous system
12. Mature neurons: signal transduction-serine/threonine kinases
13. The cytoskeleton
14. Neuronal plasticity
15. Genetic basis of human neuronal diseases
16. Ageing and the death of neurones

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