DESCRIPTION:
The mechanisms of the various forms of glaucoma were unknown at the outset of the twentieth century. Late in the twentieth century, two nascent areas of research were beginning to provide glimpses of what the twenty-first century held in store for the future of glaucoma: the mechanisms of glaucomatous optic neuropathy and the molecular basis of the glaucomas. In Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities, the authors review the most current knowledge available in the field and provide a basis in which researchers can effectively study the glaucomas.
The intent of the book is not primarily to describe the clinical appearances of the glaucomas nor how to manage them. Rather, it is to provide basic scientists, who are working in the field of glaucoma, with a current understanding of the clinical aspects of glaucoma, and to provide clinician scientists with the basic knowledge, as they attempt to translate it into rational treatments for glaucoma. In this important new book leaders in the various fields of glaucoma review our current understanding of glaucoma from epidemiology and genetics through molecular, cellular and tissue responses to the mechanisms of the glaucomas and the mechanisms by which we manage them. Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities will be of great value as its contents will aid the reader in prevention of blindness from glaucoma.
CONTENTS:
1. Age and Racial Variation in the Prevalence of Open-Angle Glaucoma in the United States
2. Epidemiology of and Risk Factors for Primary Open Angle Glaucoma
3. The Reykjavik Eye Study on the Prevalence of Glaucoma in Iceland and Identified Risk Factors
4. Defined Glaucoma in Chinese Population
5. The Wroclaw Epidemiological Study: Screening Possibilities of Glaucoma Detection
Mechanisms of Intraocular Pressure Elevation in the Glaucomas
6. Pre Trabecular Mechanisms of Intraocular Pressure Elevation
7. Trabecular Mechanisms of Intraocular Pressure Elevation
8. Trabecular Mechanisms: Pseudoexfoliation Syndrome
9. Posttrabecular Mechanisms with Elevated Episcleral Venous Pressure
10. Angle Closure Glaucomas: Anterior (Pulling) Mechanisms
11. Angle Closure Glaucomas: Posterior (Pushing) Mechanisms With Pupillary Block
12. Angle Closure Glaucomas: Posterior (Pushing) Mechanisms without Pupillary Block
Genetics of Glaucoma
13. Genetics and Glaucoma Susceptibility
14. Myocilin Mutations and their Role in Open Angle Glaucoma
15. The Functional Role of Myocilin in Glaucoma
16. Role of Cyp1b1, Optineurin and WDR36 Gene Mutations in Glaucoma
17. Genetic Association in Primary Open Angle Glaucoma
18. Apo E Polymorphisms and Severity of Open Angle Glaucoma
Molecular and Cellular responses in the eye to Glaucoma
19. Changes in Aqueous humor dynamics with Age and Glaucoma
20. Mechanosensitive Genes in the Trabecular Meshwork at Homeostasis: Elevated Intraocular Pressure and Stretch
21. Reactive Astrocytes in the Glaucomatous Optic Nerve Head: Protective and Destructive Mechanisms
22. Optic Neuropathy and Ganglion Cell Degeneration in Glaucoma: Mechanisms and Therapeutic Strategies
23. Proteomics in Defining Pathogenic Processes Involved in Glaucomatous Neurodegeneration
24. Proteomic Advances Toward Understanding Glaucoma Mechanisms
25. Ocular gene Expression in Experimental Glaucoma
Ocular Tissue and Psychophysiological Responses in Glaucoma
26. Ocular Biomechanics in Glaucoma
27. Intraocular Pressure, Pefusion Pressure and Optic Nerve Energy Metabolism
28. Optic Nerve: Physiology and Mechanisms of Glaucomatous Atrophy
29. Psychophysiology of Glaucoma: From Form to Function
Models of Glaucoma
30. The Primate Model of Experimental Glaucoma
31. Involvement of Inflammation in a Mouse Model of Inherited Pigmentary Glaucoma
32. Use of Purified Retinal Ganglion Cells for an In Vitro Model to Study Glaucoma
Therapeutic Modalities
33. Pharmacological Therapies for Managing Glaucoma
34. Redox-Based Therapies for Neuroprotection
35. Neuroprotective Signaling Pathways in Glaucoma
36. Lasers in the Management of the Glaucomas
37. Mechanisms and Mechanics of Incisional Surgery for Glaucoma
38. Aqueous Shunts
39. New Approaches to the Surgical Management of the Glaucomas
