DESCRIPTION:
This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail.
Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include:
- Historical background
- Distinct structures and functions
- Structural basis
- Signaling
- Viral entry and virion budding
- Cholesterol transport
- Caveolins
- Lipid shells
- Cell polarity and intracellular trafficking
- Cancer cells
Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
CONTENTS:
1. Lipid Rafts, Caveolae, and Membrane Traffic
2. The Forces that Shape Caveolae
3. The Biophysical Characterization of Lipid Rafts
4. The Role of Caveolae and Noncaveolar Rafts in Endocytosis
5. Role of Cholesterol in Signal Transduction from Caveolae
6. Phosphorylation of Caveolin and Signaling from Caveolae
7. Role of Lipid Microdomains in the Formation of Supramolecular Protein Complexes and Transmembrane Signaling
8. Caveolin and its Role in Intracellular Chaperone Complexes
9. The Roles of Caveolae and Caveolin in Cell Shape, Locomotion, and Stress Fiber Formation
10. Lipid Rafts in Trafficking and Processing of Prion Protein and Amyloid Precursor Protein
11. Caveolae and the Endothelial Nitric Oxide Synthase
12. The Role of Caveolin-1 in Tumor Cell Survival and Cancer Progression
