DESCRIPTION:
The acclaimed, landmark guide to internal medicine_updated to reflect the latest guidelines and recommendations.
The Voice of Clinical Reason
For more than seven decades, Harrison""s Principles of Internal Medicine has provided healthcare professionals with the informational foundation needed to provide optimal patient care. The world""s leading authority on applied pathophysiology and clinical medicine, this trusted resource has covered countless advances and developments across the full span of medicine.
Fully updated, the new 22nd edition has been modified extensively in its structure and content and offers a standardized format for each disease chapter. The authors and editors have curated and synthesized the vast amount of information that comprises general internal medicine and each of the major specialties into a highly readable and informative resource.
Harrison""s is world-renowned as the most authoritative source for:
- Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases
- Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases
- The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow
- Updated clinical trial results and recommended guidelines
- Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings
- Coverage of both therapeutic approaches and specific treatment regimens
- Practical clinical decision trees and algorithms
- Organ- and system-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, as well as general and specific approaches to therapy
This twenty-second edition features:
- Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries
- More than 3,000, clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes
- Numerous atlases featuring curated collections of important visual aspects of diagnosis and management
- Brand new chapters, including The Value of the Physical Examination in Modern Medicine, Physician Well-Being, Exercise
- Intolerance, Primary and Secondary Hemophagocytic Lymphohistiocytosis, Symptom Control in Patients with Cancer, Principles of Immunization, COVID and Other Coronavirus Infections, Desensitization, Point-of-Care Ultrasound, Placebo and Nocebo Effects, Bedside Examination Tests in the Patient with Low Back Pain, and Antithrombotic Therapy in Adult Patients
CONTENTS:
Part 1: The Profession of Medicine
Updated! Chapter 1: The Practice of Medicine
Updated! Chapter 2: Promoting Good Health
Updated! Chapter 3: Vaccine Opposition and Hesitancy
Updated! Chapter 4: Decision-Making in Clinical Medicine
Updated! Chapter 5: Precision Medicine and Clinical Care
Updated! Chapter 6: Screening and Prevention of Disease
Updated! Chapter 7: The Safety and Quality of Health Care
Updated! Chapter 8: The Value of the Physical Examination in Modern Medicine
Updated! Chapter 9: Physician Well-Being
Updated! Chapter 10: Diagnosis: Reducing Errors and Improving Quality
Updated! Chapter 11: Racial and Ethnic Disparities in Health Care
Updated! Chapter 12: Ethical Issues in Clinical Medicine
Updated! Chapter 13: Palliative and End-of-Life Care
Part 2: Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
Updated! Chapter 14: Pain: Pathophysiology and Management
Updated! Chapter 15: Chest Discomfort
Updated! Chapter 16: Abdominal Pain
Updated! Chapter 17: Headache
New! Chapter 18: Low Back Pain
Updated! Chapter 19: Neck Pain
Section 2: Alterations in Body Temperature
New! Chapter 20: Fever
Section 3: Nervous System Dysfunction
Updated! Chapter 23: Syncope
Updated! Chapter 24: Dizziness and Vertigo
Updated! Chapter 25: Fatigue
Updated! Chapter 26: Neurologic Causes of Weakness and Paralysis
Updated! Chapter 27: Numbness, Tingling, and Sensory Loss
Updated! Chapter 28: Gait Disorders, Imbalance, and Falls
Updated! Chapter 29: Confusion and Delirium
Updated! Chapter 30: Coma
Updated! Chapter 31: Dementia
Updated! Chapter 32: Aphasia, Memory Loss, and Other Cognitive Disorders
New! Chapter 33: Sleep Disorders
Section 4: Disorders of Eyes, Ears, Nose, and Throat
Updated! Chapter 34: Disorders of the Eye
Updated! Chapter 35: Disorders of Smell and Taste
New! Chapter 36: Disorders of Hearing
Updated! Chapter 37: Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat
New! Chapter 38: Oral Manifestations of Disease
Section 5: Alterations in Circulatory and Respiratory Functions
Updated! Chapter 39: Dyspnea
Updated! Chapter 40: Cough
Updated! Chapter 41: Hemoptysis
Updated! Chapter 42: Hypoxia and Cyanosis
New! Chapter 44: Approach to the Patient with a Heart Murmur
New! Chapter 45: Palpitations
New! Chapter 46: Exercise Intolerance
Section 6: Alterations in Gastrointestinal Function
New! Chapter 47: Dysphagia
New! Chapter 48: Nausea, Vomiting, and Indigestion
New! Chapter 49: Diarrhea and Constipation
New! Chapter 50: Unintentional Weight Loss
New! Chapter 51: Gastrointestinal Bleeding
New! Chapter 52: Jaundice
New! Chapter 53: Abdominal Swelling and Ascites
Section 7: Alterations in Renal and Urinary Tract Function
New! Chapter 54: Interstitial Cystitis/Bladder Pain Syndrome
New! Chapter 55: Azotemia and Urinary Abnormalities
New! Chapter 57: Hypercalcemia and Hypocalcemia
New! Chapter 58: Acidosis and Alkalosis
Section 8: Alterations in the Skin
New! Chapter 59: Approach to the Patient with a Skin Disorder
New! Chapter 60: Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
New! Chapter 61: Skin Manifestations of Internal Disease
New! Chapter 62: Immunologically Mediated Skin Diseases
New! Chapter 64: Photosensitivity and Other Reactions to Sunlight
Section 9: Hematologic Alterations
New! Chapter 66: Anemia and Polycythemia
New! Chapter 69: Bleeding and Thrombosis
Part 3: Pharmacology
Updated! Chapter 71: Principles of Clinical Pharmacology
Updated! Chapter 72: Pharmacogenomics
Part 4: Oncology and Hematology
Section 1: Neoplastic Disorders
New! Chapter 74: Symptom Control in Patients with Cancer
New! Chapter 76: Cancer Genetics
New! Chapter 79: Infections in Patients with Cancer
New! Chapter 80: Oncologic Emergencies
New! Chapter 81: Cancer of the Skin
New! Chapter 82: Head and Neck Cancer
New! Chapter 84: Breast Cancer
New! Chapter 85: Upper Gastrointestinal Tract Cancers
New! Chapter 86: Colorectal Cancer
New! Chapter 89: Gastrointestinal Neuroendocrine Tumors
New! Chapter 91: Cancer of the Bladder and Urinary Tract
New! Chapter 93: Testicular Cancer
New! Chapter 94: Gynecologic Malignancies
New! Chapter 95: Primary and Metastatic Tumors of the Nervous System
New! Chapter 96: Soft Tissue and Bone Sarcomas and Bone Metastases
New! Chapter 98: Paraneoplastic Syndromes: Endocrinologic/Hematologic
New! Chapter 99: Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
New! Chapter 100: Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment
Section 2: Hematopoietic Disorders
New! Chapter 101: Hematopoietic Stem Cells
New! Chapter 102: Iron Deficiency and Other Acquired Anemias Due to Decreased Erythrocyte Production
New! Chapter 103: Disorders of Hemoglobin
New! Chapter 104: Megaloblastic Anemias
New! Chapter 106: Anemia Due to Acute Blood Loss
New! Chapter 108: Polycythemia Vera and Other Myeloproliferative Neoplasms
New! Chapter 111: Acute Lymphoid Leukemia
New! Chapter 113: Non-Hodgkin""s Lymphoma
New! Chapter 114: Hodgkin""s Lymphoma
New! Chapter 115: Less Common Lymphoid and Myeloid Malignancies
New! Chapter 116: Plasma Cell Disorders
New! Chapter 117: Amyloidosis
New! Chapter 119: Hematopoietic Cell Transplantation
Section 3: Disorders of Hemostasis
New! Chapter 120: Disorders of Platelets and Vessel Wall
New! Chapter 121: Coagulation Disorders
Part 5: Infectious Diseases
Section 4: Therapy for Bacterial Diseases
New! Chapter 150: Bacterial Resistance to Antimicrobial Agents
Section 5: Diseases Caused by Gram-Positive Bacteria
New! Chapter 153: Streptococcal Infections
New! Chapter 154: Enterococcal Infections
New! Chapter 158: Botulism
Section 6: Diseases Caused by Gram-Negative Bacteria
New! Chapter 160: Meningococcal Infections
New! Chapter 162: Haemophilus and Moraxella Infections
New! Chapter 163: Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
New! Chapter 168: Helicobacter pylori Infections
New! Chapter 170: Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species
New! Chapter 171: Salmonellosis
New! Chapter 173: Cholera and Other Vibrioses
Part 6: Disorders of the Cardiovascular System
Section 1: Introduction to Cardiovascular Disorders
New! Chapter 243: Approach to the Patient with Possible Cardiovascular Disease
New! Chapter 244: Basic Biology of the Cardiovascular System
New! Chapter 245: Epidemiology of Cardiovascular Disease
Section 2: Diagnosis of Cardiovascular Disorders
New! Chapter 246: Physical Examination of the Cardiovascular System
New! Chapter 247: Electrocardiography
New! Chapter 249: Diagnostic Cardiac Catheterization and Coronary Angiography
Section 3: Disorders of Rhythm
New! Chapter 250: Principles of Clinical Cardiac Electrophysiology
New! Chapter 251: The Bradyarrhythmias: Disorders of the Sinoatrial Node
New! Chapter 252: The Bradyarrhythmias: Disorders of the Atrioventricular Node
New! Chapter 253: Approach to Supraventricular Arrhythmias
New! Chapter 254: Physiologic and Nonphysiologic Sinus Rhythm
New! Chapter 255: Focal Atrial Tachycardia
New! Chapter 256: Paroxysmal Supraventricular Tachycardias
New! Chapter 259: Approach to Ventricular Arrhythmias
New! Chapter 260: Premature Ventricular Contractions, Nonsustained Ventricular Tachycardia, and Accelerated Idioventricular Rhythm
New! Chapter 261: Sustained Ventricular Tachycardia
New! Chapter 262: Polymorphic Ventricular Tachycardia and Ventricular Fibrillation
New! Chapter 263: Electrical Storm and Incessant Ventricular Tachycardia
Section 4: Disorders of the Heart, Muscles, Valves, and Pericardium
New! Chapter 265: Heart Failure: Management
New! Chapter 266: Classification of Cardiomyopathy
New! Chapter 267: Genetic Cardiomyopathies
New! Chapter 268: Acute and Chronic Myocarditis
New! Chapter 269: Dilated Cardiomyopathies
New! Chapter 273: Aortic Regurgitation
New! Chapter 276: Mitral Valve Prolapse
New! Chapter 278: Pulmonic Valve Disease
New! Chapter 279: Multiple and Mixed Valvular Heart Disease
New! Chapter 281: Pericardial Disease
New! Chapter 282: Atrial Myxoma and Other Cardiac Tumors
New! Chapter 283: Cardiac Trauma
Section 5: Coronary and Peripheral Vascular Disease
New! Chapter 293: Chronic Venous Disease and Lymphedema
Part 7: Disorders of the Respiratory System
Section 1: Diagnosis of Respiratory Disorders
New! Chapter 295: Approach to the Patient with Disease of the Respiratory System
Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders
Section 1: The Immune System in Health and Disease
New! Chapter 362: Primary Immune Deficiency Diseases
Section 2: Disorders of Immune-Mediated Injury
New! Chapter 363: Urticaria, Angioedema, and Allergic Rhinitis
Part 14: Poisoning, Drug Overdose, and Envenomation
New! Chapter 469: Heavy Metal Poisoning
New! Chapter 470: Poisoning and Drug Overdose
New! Chapter 471: Disorders Caused by Venomous Snakebites and Marine Animal Exposures
New! Chapter 472: Ectoparasite Infestations and Arthropod Injuries
Part 15: Disorders Associated with Environmental Exposures
New! Chapter 475: Altitude Illness
New! Chapter 477: Hypothermia and Peripheral Cold Injuries
New! Chapter 478: Heat-Related Illnesses
Part 16: Genes, the Environment, and Disease
New! Chapter 480: The Integration of Inherited Genetics into Clinical Practice
New! Chapter 482: Telomere Disease
New! Chapter 483: Gene and Cell-Based Therapy in Clinical Medicine
New! Chapter 484: The Human Microbiome in Health and Disease
Part 17: Global Medicine
New! Chapter 485: Global Issues in Medicine
New! Chapter 487: Primary Care and Global Health
Part 18: Aging
New! Chapter 488: Biology of Aging
Part 19: Consultative Medicine
Updated! Chapter 490: Approach to Medical Consultation
Updated! Chapter 491: Medical Disorders During Pregnancy
Updated! Chapter 492: Medical Evaluation of the Patient Undergoing Noncardiac Surgery
Part 21: Video Collection
New! Chapter V1: Video Library of Gait Disorders
New! Chapter V3: Video Library of Neuro-Ophthalmology
New! Chapter V4: Examination of the Comatose Patient
New! Chapter V5: Video Atlas of Gastrointestinal Endoscopic Lesions
New! Chapter V6: The Neurologic Screening Exam
New! Chapter V7: Video Atlas of the Detailed Neurologic Examination
New! Chapter V8: Bedside Examination Tests in the Patient with Low Back Pain
Part 22: Supplementary Topics
Updated! Chapter S1: Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples
New! Chapter S2: Cerebrospinal Fluid Disturbances: Case Examples
Updated! Chapter S5: Chemical Terrorism
Updated! Chapter S9: Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases
Updated! Chapter S10: The Clinical Laboratory in Modern Health Care
New! Chapter S12: Laboratory Diagnosis of Parasitic Infections
Part 23: Atlases
Updated! Chapter A2: Atlas of Blood Smears of Malaria and Babesiosis
Updated! Chapter A3: Atlas of Oral Manifestations of Disease
Updated! Chapter A4: Atlas of Urinary Sediments and Renal Biopsies
Updated! Chapter A5: Atlas of Skin Manifestations of Internal Disease
New! Chapter A6: Atlas of Hematology
New! Chapter A8: Atlas of Cardiac Arrhythmias
New! Chapter A12: Atlas of Chest Imaging
