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A consummate classic with a fresh approach to pediatric dermatology

Children´s skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment.
This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions - both common and rare - with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data - especially at the genetic level.

This new fourth edition includes:
- Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants
- Increased coverage of lasers and other technologies used to treat skin disease
- More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management
- Additional online features, including patient information links and multiple choice questions

Harper""s Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.

Volume 1
Section 1 Development, Structure and Physiology of the Skin
1. Embryogenesis of the Skin
2. Molecular Genetics in Paediatric Dermatology
3. Cutaneous Microbiome
4. Physiology of Neonatal Skin
Section 2 Skin Disorders of the Neonate and Young Infant
1. Neonatal skin care
2. Transient skin disorders
3. Congenital and Acquired Infections in the Neonate
4. Transplacentally acquired dermatoses
5. Developmental anomalies
6. Differential Diagnosis of Neonatal Erythroderma
7. Vesiculopustular, bullous and erosive diseases of the neonate
8. Iatrogenic Disorders of the Newborn
Section 3 Atopic Dermatitis and Related Disorders
1. Epidemiology of Atopic Dermatitis
2. Genetics of Atopic Eczema
3. Clinical Features and Diagnostic Criteria of Atopic Dermatitis
4. Severity Scoring and Quality of Life Assessment in Atopic Dermatitis
5. Atopic dermatitis and related disorders: Special types of presentation
6. Atopic dermatitis: Complications
7. Management of Atopic Dermatitis
Section 4 Other Types of Dermatitis
1. Napkin dermatitis
2. Adolescent Seborrheic Dermatitis
3. Irritant contact dermatitis
4. Allergic contact dermatitis
5. Hypereosinophilic disorders
6. Juvenile plantar dermatosis
7. Perioral dermatitis
Section 5 Psoriasis
1. Psoriasis - Epidemiology
2. Psoriasis: Aetiology and pathogenesis
3. Psoriasis: Classification, Scores, Diagnosis
4. Psoriasis: Clinical Features and Comorbidities
5. Psoriasis: Management
Section 6 Other papulosquamous disorders
1. Pityriasis rubra pilaris
2. Lichen Planus
3. Lichen nitidus
4. Lichen striatus
5. Pityriasis rosea
Section 7 Bacterial skin Infections
1. Pyodermas and Bacterial Toxin-mediated Syndromes
2. Cutaneous manifestations of Gram negative infections
3. Pitted keratolysis, erythrasma, erysipeloid
4. Lyme Borreliosis
5. Bartonella infections
6. Mycobacterial Skin Infections
7. Rickettsial disease
8. Endemic Treponematoses: Yaws, Pinta and Endemic Syphilis
9. Tropical ulcer
Section 8 Fungal skin infections
1. Superficial fungal infections
2. Deep Fungal Infections
Section 9 Viral skin infections and opportunistic infections
1. Molluscum contagiosum
2. Human Papillomavirus Infection
3. Herpes Simplex Virus Infections
4. Varicella-zoster virus infections
5. Poxviruses
6. HIV and HTLV-1 Infection
7. Viral exanthemas
8. Eruptive hypomelanosis
9. Cutaneous Infections in Immunocompromised Children
Section 10 Parasitic skin infestations and sting reactions
1. Leishmaniasis
2. Helminthic infections
3. Scabies and Pseudoscabies
4. Pediculosis and Cimicosis
5. Noxious and venomous creatures
6. Aquatic dermatoses
Section 11 Urticaria, erythemas and drug reactions
1. Urticaria, erythemas and drug reactions
2. Annular erythemas
3. Giannotti-Crosti Syndrome
4. Erythema Multiforme, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
5. Hypersensitivity reactions to drugs
Section 12 Acne and acneiform disorders
1. Acne
2. Rosacea
3. Hidradenitis suppurativa
Section 13 Nutritional disorders
1. Skin Manifestations of Nutritional Disorders
2. Skin Manifestations of Paediatric Metabolic Syndrome
Section 14 Blistering disorders
1. Differential diagnosis of vesiculobullous lesions
2. Autoimmune bullous diseases
3. Childhood Dermatitis Herpetiformis
4. Epidermolysis bullosa and Kindler syndrome
Section 15 Photodermatoses, photoprotection and environmental skin disorders
1. The Idiopathic Photodermatoses and Skin Testing
2. The Porphyrias
3. Photoprotection
4. Skin Reactions to Plants, Cold, Heat, and Chemicals
Section 16 Granulomatous diseases
1. Sarcoidosis
2. Granuloma annulare
3. Orofacial granulomatosis
Section 17 Neutrophilic dermatoses
1. Sweet syndrome
2. Pyoderma gangrenosum
Section 18 Lymphocytic disorders
1. Pityriasis lichenoides
2. Jessner Lymphocytic Infiltrate of the Skin
3. Primary Cutaneous Lymphoma
4. Childhood Leukaemias and Lymphomas
Section 19 Histiocytic disorders
1. Langerhans cell histiocytosis
2. Juvenile Xanthogranuloma and other Non Langerhans Cell Histiocytoses
Section 20 Mastocytosis
1. Paediatric mastocytosis
Section 21 Disorders of connective tissue
1. Ehlers-Danlos-Syndrome
2. Pseudoxanthoma Elasticum and Cutis Laxa
3. Buschke-Ollendorff-Syndrome, Marfan Syndrome, Osteogenesis imperfect
4. Anetodermas and Atrophoderma
5. Hyalinoses, Stiff Skin Syndrome, Restrictive Dermopathy
6. Striae in Children and Adolescents
7. Morphoea (Localised Scleroderma)
8. Systemic sclerosis in childhood
Section 22 Disorders of fat tissue
1. Lipoma and lipomatosis
2. Panniculitis
3. Lipodystrophies
Section 23 Mosaic disorders, naevi and hamartomas
1. An introduction to Mosaicism
2. Melanocytic naevi
3. Epidermal naevi
4. Other naevi and hamartomas
5. Proteus syndrome and other localised overgrowth disorders
6. Mosaic disorders of pigmentation
Section 24 Non-vascular skin tumours
1. Differential diagnosis of skin nodules and cysts
2. Adnexal disorders
3. Calcification and Ossification in the Skin
4. Angiolymphoid Hyperplasia with Eosinophilia
5. Fibromatoses
6. Carcinomas of the skin
7. Childhood Melanoma
8. Other malignant skin tumours
Section 25 Vascular tumours and malformations
1. Vascular malformations
2. Infantile haemangiomas
3. Other vascular tumours
4. Disorders of lymphatics
Section 26 Disorders of Pigmentation
1. Inherited and Acquired Hyperpigmentation
2. Vitiligo
3. Albinism
4. Disorders of hypopigmentation
5. Dyschromatosis
Section 27 Disorders of Keratin and Keratinization
1. Review of Keratin Disorders
2. Mendelian Disorders of Cornification (MEDOC): the Keratodermas
3. Mendelian Disorders of Cornification (MeDOC): The ichthyoses
4. Keratosis pilaris and Darier´s Disease
5. The Erythrokeratodermas
6. Netherton Syndrome
7. Porokeratosis
Section 28 Focal or generalized hypoplasia, premature ageing
1. Ectodermal dysplasia
2. Focal dermal hypoplasia
3. Incontinentia pigmenti
4. Premature ageing syndromes
Section 29 Genetic diseases predisposing to malignancy
1. Xeroderma pigmentosum and related diseases
2. Gorlin (Naevoid basal cell carcinoma) syndrome
3. Rothmund-Thomson Syndrome, Bloom Syndrome, Dyskeratosis Congenita, Fanconi Anaemia, Poikiloderma with Neutropenia
4. Other Genetic Disorders Predisposing to Malignancy
Section 30 Neurofibromatosis, RASopathies, and Hamartoma-overgrowth-syndromes
1. The Neurofibromatoses
2. Tuberous Sclerosis Complex
3. Other RASopathies
Section 31 Vasculitic and Rheumatic Syndromes
1. Cutaneous vasculitis
2. Purpura fulminans
3. Kawasaki disease
4. Polyarteritis Nodosa, Granulomatosis with Polyangiitis, and Microscopic Polyangiitis
5. Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus and Juvenile Dermatomyositis
6. Behçet""s Disease and Relapsing Polychondritis
7. Erythromelalgia
Section 32 Cutaneous Manifestations of Systemic Disease
1. Metabolic Disorders and the Skin
2. Cystic Fibrosis
3. Cutaneous manifestations of endocrine disease
4. Autoinflammatory diseases and amyloidosis
5. Immunodeficiency syndromes
6. Graft-Versus-Host Disease
Section 33 The oral cavity
1. The Oral Mucosa and Tongue
Section 34 Hair, scalp and nail disorders
1. Hair Disorders
2. Alopecia areata
3. Nail disorders
Section 35 Anogenital disease in children
1. Genital disease in children
2. Sexually transmitted diseases in children and adolescents
Section 36 Cutaneous Signs of Child Maltreatment and Sexual Abuse
1. Maltreatment, physical and sexual abuse
Section 37 Psychological Aspects of Skin Disease in Children
1. Assessing and scoring Life Quality
2. Coping with the burden of disease
3. Physiological Habits, Self-Mutilation and Factitious Disorders
Section 38 Principles of treatment in children
1. Topical therapy
2. Systemic therapy in Pediatric Dermatology
3. New genetic approaches to treating diseases of the skin
4. Surgical therapy
5. Laser therapy
6. Sedation and anaesthesia
Section 39 Diagnostic procedures in dermatology
1. Approach to the pediatric patient
2. Dermoscopy of Melanocytic Lesions in the Paediatric Population
3. The Role of Histopathology and Molecular Techniques in Pediatric Dermatology
Section 40 Nursing care of cutaneous disorders in children
1. Nursing Care of the Skin in Children

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