carrito Compra

(0 Productos)

Gastos de envío GRATIS

Solo para España


  1. Autor:


  2. Isbn:


  3. Páginas:


  4. Año:


  5. Edición:


  6. Idioma:


  7. Disponibilidad:

    De 7 a 10 Días

Precio s/iva:

820.44 €

779,42  €

This unique book provides comprehensive overview of the field of immunology related to engineered nanomaterials used for biomedical applications. It contains literature review, case studies and protocols. The book can serve as a source of information about nanoimmunotoxicology for both junior scientists and experts in the field. The authors have more than 10 years of experience with preclinical characterization of engineered nanomaterials used for medical applications, and they share their experience with the readers. In addition, the international team of experts in the field provides the opinion and share the expertise on individual topics related to nanoparticle physicochemical characterization, hematocompatibility, and effects on the immune cell function . The second edition contains updated chapters from the first edition plus new chapters covering areas of tumor immunology, nanoparticle interaction with lymphatic system, mathematical modeling of protein corona, utilization of nanoparticles for the delivery of antiviral drugs, extensive analysis of nanoparticle anti-inflammatory and immunosuppressive properties, novel ways of protecting therapeutic nanoparticles from the immune recognition, as well as case studies regarding nanoparticle sterilization, complement activation, protein binding and immunotherapy of cancer. The second edition comes in 3 volumes. Volume 1 is focused on nanoparticle characterization, sterility and sterilization, pyrogen contamination and depyrigenation. It also contains overview of regulatory guidelines, protocols for in vitro and in vivo immunotoxicity studies, and correlation between in vitro and in vivo immunoassays. Volume 2 is focused on hematocompatibility of nanomaterials. It provides comprehensive review and protocols for investigating nanoparticle interaction with erythrocytes, platelets, endothelial cells, plasma coagulation factors and plasma proteins forming so called "corona" around nanoparticles. Volume 3 is dedicated to nanoparticle interaction with and effects on the immune cell function. It also contains examples of nanoparticle use for delivery of antiviral and anti-inflammatory drugs.

Volume 1: Key Considerations for Nanoparticle Characterization Prior to Immunotoxicity Studies:
Immunological Properties of Engineered Nanomaterials: An Introduction
Importance of Physicochemical Characterization Prior to Immunological Studies
Nanoparticle Sterility and Sterilization of Nanomaterials
Sterilization Case Study 1: Effects of Different Sterilization Techniques on Gold Nanoparticles
Sterilization Case Study 2: Effects of Sterilization Techniques on Silver Nanoparticles
Surface Adsorbates on Nanomaterials and Their Possible Roles in Host Inflammatory and Toxicological Processing
Endotoxin and Engineered Nanomaterials
Endotoxin Case Study: Interference of Nanoparticles with the Traditional Limulus Amebocyte Lysate Gel Clot Assay
Immunotoxicity Testing for Drug-Nanoparticle Conjugates: Regulatory Considerations
In Vitro Assays for Monitoring Nanoparticle Interaction with Components of the Immune System
Evaluating the Adverse Effects of Nanomaterials on the Immune System with Animal Models
Understanding the Correlation between in vitro and in vivo Immunotoxicity Tests for Engineered Nanomaterials

Volume 2: Haematocompatibility of Engineered Nanomaterials:
Nanoparticle Interaction with Plasma Proteins as It Relates to Biodistribution
Protein Binding Case Study 1: Understanding Relationship between Protein Corona and Nanoparticle Toxicity
Mathematical Modeling of the Protein Corona: Implications for Nanoparticulate Delivery Systems
Effects of Nanomaterials on Erythrocytes
The Effects of Engineered Nanomaterials on Cultured Endothelial Cells
The Effects of Engineered Nanomaterials on the Plasma Coagulation System
The Effects of Engineered Nanomaterials on Platelets
Nanoparticles and the Blood Coagulation System
Complement Activation
Case Study: Complement Activation Related Hypersensitivity Reactions to PEGylated Liposomal Doxorubicin _ Experimental and Clinical Evidence, Mechanisms and Approaches to Inhibition
Lymphatic System: A Prospective Area for Advanced Targeting of Particulate Drug Carriers

Volume 3: Engineered Nanomaterials and the Immune Cell Function:
Bidirectional Interaction between Nanoparticles and Carrier-Mediated Agents and Cells of the Mononuclear Phagocytic System
Case Study: Application of LeukoLike Technology to Camouflage Nanoparticles from the Immune Recognition
The Effects of Nanoparticles on Dendritic Cells
The Effects of Nanoparticles on Bone Marrow Cells
Nanoparticles, Immunomodulation and Vaccine Delivery
Undesirable Adjuvanticity of Nanoparticles and Its Implication in Modulation of T Helper Responses
Immunosuppressive and Anti-Inflammatory Properties of Engineered Nanomaterials
Nanoparticles as Drug Delivery Vehicels for the Therapy of Inflammatory Disorders
Opportunities and Challenges in Nanotechnology-enabled Antiretroviral Delivery
Nanostructures and Allergy
Nanoparticles and Antigenicity
Local Hyperthermia Treatment of Tumors Induces CD8+ T Cell-Mediated Resistance Against Distal and Secondary Tumors

Libreria Médica Berri 2018 ®