DESCRIPTION:
This extensively updated and expanded second edition reflects new research, advances in clinical care, and the growing recognition that diabetes mellitus is a risk factor for cardiovascular disease. Written for the practicing clinician as a comprehensive review of diabetic vascular disease, the book both explains the basic pathophysiology of the disease and details the latest diagnostic and therapeutic approaches. The authors have added new chapters on percutaneous interventional therapy in cardiac and peripheral vascular disease, cardiovascular surgery in diabetes, therapeutic interventions to improve endothelial function in diabetes, PARP activation and nitrosative stress in the development of the cardiovascular system, and PPARs and their emerging role in vascular biology, inflammation, and atherosclerosis.
CONTENTS:
PART I. PATHOPHYSIOLOGY
1 Effects of Insulin on the Vascular System
2 Effects of Diabetes and Insulin Resistance on Endothelial Functions
3 Diabetes and Advanced Glycoxidation End-Products
4 The Renin-Angiotensin System in Diabetic Cardiovascular Complications
5 PPARs and Their Emerging Role in Vascular Biology, Inflammation, and Atherosclerosis
6 Diabetes and Thrombosis
7 Role of Estrogens in Vascular Disease in Diabetes: Lessons Learned From the Polycystic Ovary Syndrome
8 Poly(ADP-Ribose) Polymerase Activation and Nitrosative Stress in the Development of Cardiovascular Disease in Diabetes
9 Adiponectin and the Cardiovascular System
10 Nitric Oxide and Its Role in Diabetes Mellitus
11 Diabetes and Atherosclerosis
12 The Use of Animal Models to Study Diabetes and Atherosclerosis and Potential Anti-Atherosclerotic Therapies
PART II. CLINICAL
A. RISK FACTORS
13 The Metabolic Syndrome and Vascular Disease
14 Diabetes and Hypertension
15 Diabetes and Dyslipidemia
B. MICROCIRCULATION
16 Diabetic Retinopathy
17 Diabetic Nephropathy
18 Diabetic Neuropathy
19 Microcirculation of the Diabetic Foot
C. CARDIOVASCULAR SYSTEM: PERIPHERAL VASCULAR SYSTEM
20 Epidemiology of Peripheral Vascular Disease
21 Noninvasive Methods to Assess Vascular Function and Pathophysiology
22 Peripheral Vascular Disease in Patients With Diabetes Mellitus
23 Therapeutic Interventions to Improve Endothelial Function in Diabetes
D. CARDIOVASCULAR SYSTEM: CARDIAC
24 Preoperative Assessment and Perioperative Management of the Surgical Patient With Diabetes Mellitus
25 Diabetes and Percutaneous Interventional Therapy
26 Cardiac Surgery and Diabetes Mellitus
27 Heart Failure and Cardiac Dysfunction in Diabetes
28 Diabetes Mellitus and Heart Disease