DESCRIPTION:
Connective tissue is a multicomponent, polyfunctional complex of cells and extracellular matrix that serves as a framework for all organs, combining to form a unified organism. It is a structure responsible for numerous vital functions such as tissue-organ integration, morphogenesis, homeostasis maintenance, biomechanical support, and more. The regeneration potential of connective tissue affects healing of damaged tissue and organs, while trauma, stress, and other factors that cause damage to connective tissue can lead to numerous disorders.
Connective Tissue: Histophysiology, Biochemistry, Molecular Biology brings together crucial knowledge of mammalian connective tissue (including human) and its components, both cellular and noncellular, in one authoritative reference. The breadth and depth of information has fundamental scientific significance as well as applied relevance in clinical medicine. The first half of the book covers the structure, classification, biochemical aspects, histogenesis, and cellular elements of connective tissue. It presents data from the macro- to nanolevel organization of the extracellular matrix_its structural and functional aspects_and addresses metabolic functions and the biochemistry and molecular biology of connective tissue ageing.
The second half of the book reviews current data on the biochemistry and molecular biology of skeletal connective tissue, including bone and cartilage metabolism and regulation. It presents an in-depth analysis of data on the molecular mechanisms of connective tissue ontogenesis, from embryonic development through ageing. It also reports novel findings on bone marrow stroma and describes electron microscopy results of the nanostructure of bone mineral, mineralized cartilage, and teeth compared with coral and seashells. Comprising both classic and modern data on the histopathology, biochemistry, and molecular biology of connective tissue, this book provides a unique resource for clinicians and researchers alike.
CONTENTS:
Peculiarities of Connective Tissue Histophysiology, Biochemistry, and Molecular Biology
Definitions, Organization Principles, and Classification of Connective Tissue
Basic Definitions, Principles and Emphasis of Modern Biochemistry and Molecular Biology
General Biochemical Aspects of Connective Tissue
Formation and Histogenesis of Connective Tissue
Embryology and Histogenesis of Connective Tissue
Molecular and Biochemical Regularities of Initial Stages of Connective Tissue Structures Formation
Cellular Elements of Connective Tissue
Proper Cells of Connective Tissue
Fibroblastic Differon
Adventitious Cells
Adipocytes(Lipocytes, Adipocytes)
Cells Associated with Connective Tissue
Extracellular Matrix of Connective Tissue: Histophysiology, Biochemistry and Molecular Biology
Fibrous Structures
Integrating Buffer Metabolic Medium (Ground Substance) of Connective Tissue Extracellular Matrix
Basement Membranes
Interstitial (Interfibrous and Intercellular) Space of Connective Tissue
Structural Peculiarities of Connective Tissue Various Types and its Organ Specificity
General Regularities of Molecular and Supramolecular Organization of Connective Tissue Extracellular Matrix
Molecular Mechanisms of Cells and Matrix Interaction
Catabolism of Extracellular Matrix Macromolecular Components
Regulation of Connective Tissue Metabolic Functions
Systemic Factors of Regulation
Local Factors of Regulation
Biochemical and Molecular Mechanisms and Manifestations of Connective Tissue Ageing
Bone - An Organ of the Support and Locomotor Apparatus Containing All Types of Connective Tissue
Overview of Bone Structure and Function
General Structural and Functional Characteristics of Bone Components
Cartilage - Cartilaginous Tissue: Structural, Biochemical and Molecular Biological Characteristics
Overview of Structure and Composition of Cartilage Tissue
Hyaline Cartilages - Cartilaginous Tissues
Elastic Cartilages - Cartilaginous Tissues
Fibrous Cartilages - Cartilaginous Tissues
Bone Tissue: The Structural-Functional, Biochemical and Molecular Biological Characteristics of Its Components
General Overview of Bone Tissue Structure and Composition
Differons of Bone Cells
Extracellular Matrix of Bone Tissue
Interstitial Space of Bone Tissue
Regulation Mechanisms of Bone Tissue Metabolism and Functions
Remodeling of Bone Tissue
Tooth Connective Tissue
Biochemical Characteristics of Synovial Membrane and Synovia
Synovial membrane
Synovia (Synovial Fluid)
Molecular Biological and Biochemical Regularities of Connective Tissue Structures Ontogenesis
Molecular Biological and Biochemical Mechanisms of Mesenchyme Condensation. Regulation Systems of Connective Tissue
Structure Morphogenesis
Differentiation of Connective Tissue Cells
Molecular Biological and Biochemical Regularities of Skeleton Formation and Growth
Molecular Biological and Biochemical Mechanisms of Joint Formation
