DESCRIPTION:
Major depressive disorder (MDD) is the leading cause of disability globally in both developed and developing nations. The staggering economic costs attributable to MDD are largely a consequence of impairment in role function. Evidence indicates that disturbance in the domain of cognitive function in individuals with MDD is the principal determinant of health outcome. This is the first book to comprehensively explore the domain of cognition in MDD. The literature describing cognitive dysfunction is reviewed with particular focus on clinical determinants, pathophysiology and causative factors. The patient subpopulations most susceptible are defined. A summary of contemporary assessment tools for research and clinical purposes is provided. Multimodality treatments and prevention strategies are described. This book is an invaluable resource for psychiatrists, neuropsychologists and other members of the mental health team, as well as for policy makers, vocation rehabilitation experts, disability providers and other stakeholders interested in improving health outcomes in MDD.
- The first book to bring together all aspects related to cognition in MDD
- Contributors are the world""s experts on the topic of cognition in MDD
- Covers recognition, prevention, measurement and management
- Recommends neuropsychological, psychological and pharmacological approaches to management
CONTENTS:
Part I. Clinical Relevance of Cognitive Dysfunction in Major Depressive Disorder:
1. Does cognitive dysfunction predate the onset of incident depression?
2. Understanding the importance of cognitive dysfunction and cognitive change in major depressive disorder
3. Cognition in MDD implications for primary care
4. Neurocognition in pediatric depression
5. Neuroanatomy of cognition in major depressive disorder (hot and cold)
6. Hot and cold cognition in major depressive disorder
7. Social cognition and emotional processing in major depressive disorder
8. The role of social cognition in major depressive disorder
9. Are cognitive deficits in major depressive disorder progressive?
10. Implications of cognitive impairments on functional outcomes in major depressive disorder
Part II. Underlying Biological Substrates Associated with Cognitive Dysfunction in Major Depressive Disorder:
11. Cognition and biomarkers in major depressive disorder (MDD): endophenotype or epiphenomenon?
12. Inflammation and cognition in major depressive disorder
13. HPA axis and cognitive dysfunction in mood disorders
14. White matter neurobiology and cognitive dysfunction in major depressive disorder
15. Insulin resistance and implications for hippocampal volume/function the default mode network
Part III. Evaluating Cognitive Dysfunction in Major Depressive Disorder:
16. Measuring the mind: detecting cognitive deficits and measuring cognitive change in patients with depression
17. Subjective measures of cognitive dysfunction in major depressive disorder
Part IV. Treatment Opportunities for Ameliorating Cognitive Dysfunction in Major Depressive Disorder:
18. Neuroscience of functional outcomes and treatment targets in major depressive disorder
19. Treatment of cognitive dysfunction in adults with major depressive disorder
20. A novel treatment targeting cognitive dysfunction in mood disorders
21. Cognitive remediation for major depressive disorder
22. Exercise and cognition
