DESCRIPTION:
Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals is a comprehensive handbook on all aspects of adverse effects by drugs and chemical substances on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized.
The first, general part deals with themes as clinical relevance, renal handling, pharmacovigilance, urinary biomarkers, pharmacological, immunological and cellular aspects of nephrotoxicity, as well as animal and cell culture models. The second part includes the specific drugs the third part gives the description of environmental and occupational nephrotoxins. The last part deals with the patient with some degree of renal failure, exposed to drugs and chemicals, the progression of renal disease, and how to adapt drug dosage.
In this third and completely revised edition, nine new chapters were added, from proton pump inhibitors to bisphosphonates, phosphate containing laxatives, oxalate, star fruit and smoking. All chapters were extended with up-to-date references.
The book is of interest for the nephrologist, internist, general practitioner, toxicologist, pharmacologist, anesthesiologist, epidemiologist, public health official, pharmaceutical industry, and national drug safety committees, among others.
CONTENTS:
A GENERAL
1 Clinical relevance
2 Drug-associated acute kidney injury in the intensive care unit
3 Renal handling of drugs and xenobiotics
4 Pharmacological aspects of nephrotoxicity
5 Pharmacovigilance: from signal to action
6 Urinary biomarkers and nephrotoxicity
7 Toxin-induced immunological renal disease
8 Cellular mechanisms of nephrotoxicity
9 Animal models for the assessment of acute renal dysfunction and injury
10 Renal cell culture models: contribution to the understanding of nephrotoxic mechanisms
11 Use of dialytic therapies for poisoning
B SPECIFIC DRUGS
12 Aminoglycosides and vancomycin
13 Beta-lactam antibiotics
14 Amphotericin B
15 Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones
16 Antiviral agents
17 Analgesics and 5-aminosalicylic acid
18 Non-steroidal anti-inflammatory drugs
19 Gold salts, D-penicillamine and allopurinol
20 Angiotensin I converting enzyme inhibitors and angiotensin II receptor antagonists
21 Diuretics and alcohol ingestion
22 Anticancer drugs
23 Anesthetic agents
24 Bisphosphonates and the kidney
25 Proton pump inhibitors: acute interstitial nephritis and other renal effects
26 Oral sodium phosphate bowel purgatives and acute phosphate nephropathy
27 Illicit drug abuse and renal disease
28 Nephrotoxicity of calcineurin and mTOR inhibitors
29 Immunomodulators: interleukins, interferons, and IV immunoglobulin
30 Imaging agents
31 Lithium-associated kidney effects
32 Oxalate
33 Herbal remedies containing aristolochic acid and mushroom nephrotoxicity
C ENVIRONMENTAL AND OCCUPATIONAL NEPHROTOXINS
34 Lead nephropathy
35 Cadmium-induced renal effects
36 Mercury-induced renal effects
37 Organic solvents, silicon-containing compounds and pesticides
38 Balkan nephropathy
39 Nephrotoxins in Africa
40 Paraphenylene diamine hair dye poisoning
D THE RENAL FAILURE PATIENT
41 Trace metal disturbances in end-stage renal failure patients
42 Smoking and the kidney
43 Star fruit
44 Drug dosage in renal failure
