DESCRIPTION:
Signalling within and between cells is an essential part of many biological processes, from the development of the body to the activity of our immune system.
Cell Signalling, Third Edition, presents a carefully structured introduction to this intricate subject, introducing those conserved features that underlie many different extra- and intracellular signalling systems. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms before examining how these components come together to create signalling pathways, which are so crucial to the survival of many living organisms. The text is enhanced by two-color artwork and 3-D protein models. A Companion Website provides resources for students and instructors.
New to this edition:
* Expanded coverage of the role of cell signalling during development, experimental techniques, and the control of gene expression
* New "Literature Links" encourage students to engage with primary literature and to develop critical thinking and reading skills
* New four-part structure organizes the subject according to its conceptual basis, the mechanisms of signalling, and their role in natural phenomena
CONTENTS:
Part I: An overview of cell signalling
1. Aspects of cellular signalling
2. Pathways are the key to signalling
3. A look at some of the history and techniques of cell signalling
Part II: Components which comprise signalling pathways
4. Extracellular signals: hormones, cytokines and growth factors
5. Detection of extracellular signals: the role of receptors
6. Protein Phosphorylation, kinases and phosphatases
7. Cyclic nucleotides, cyclases and G proteins
8. Inositol phosphate metabolism and roles of membrane lipids
9. Intracellular calcium: Its control and role as an intracellular signal
10. Reactive oxygen species, reactive nitrogen species and redox signalling
Part III: Selected examples of signalling pathways and events
11. Insulin and the signal transduction cascades it invokes
12. Perception of the environment
13. Signalling in development and for the regulation of gene expression
14. Life, death and apoptosis
Part IV: Final thoughts
15. Cell Signalling: importance, complexity, and future
