DESCRIPTION:
This volume intends to provide a panorama of our current understanding of the role of genetic information in the management of cardiovascular disease. A recurring plea from the contributors is the need for more hypothesis-driven, rigorously conducted and analysed clinical research. Perhaps this compilation of knowledge will provide a springboard for the design of informative clinical studies.
CONTENTS:
The Role of Genotyping in Pharmacological Therapy
Pharmacogenetics and the Treatment of Cardiovascular Disease
Genetic Polymorphisms and Cardiovascular Drug Metabolism
Genes That Modify Susceptibility to Atherosclerosis: Targets for Drug Action
Lipid-Lowering Responses Modified by Genetic Variation
The Genetic Basis of Essential Hypertension and Its Implications for Treatment
Genetic Predisposition to Cardiac Hypertrophy
Genetic Determinants of Susceptibility, Prognosis and Treatment in Heart Failure
The Genetics of Cardiac Channelopathies: Implications for Therapeutics
Insulin Resistance and Cardiovascular Disease: New Insights from Genetics
Genetic Disruption of Nitric Oxide Synthases and Cardiovascular Disease: Lessons from a Candidate Gene
Association of Thrombotic Disease with Genetic Polymorphism of Haemostatic Genes: Relevance to Pharmacogenetics
The Influence of Genetic Factors on Leukocyte and Endothelial Cell Adhesion Molecules
Genetic Regulation of Metalloproteinase Activity: Pathogenic and Therapeutic Implications
Current Perspectives on Gene and Cell-Based Therapies for Myocardial Protection, Rescue and Repair
