DESCRIPTION:
The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases.
The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging. The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations. The third section of this volume highlights the roles of sympathetic nervous system with respect to a-adrenoceptor and ß-adrenoceptor mechanisms in the development of cardiac hypertrophy. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.
CONTENTS:
Part I Developmental Aspects of Cardiac Adaptation
1. Comparative Aspects of Cardiac Adaptation
2. Molecular Mechanisms of Cardiac Development
3. Prenatal Adaptations to Overload
4. Hypoxia and Mechanical Factors Drive Coronary Vascular Development
5. Cardiac Metabolic Adaptation During Postnatal Development
6. Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia
7. Heart and Arterial Aging
Part II Cardiac Adaptations to Overload
8. Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy
9. Cardiac Adaptation to Volume Overload
10. Functional Adaptation During the Development of Cardiac Hypertrophy and Heart Failure in Females
11. Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations: Sex Hormones, Exercise and Cardiac Adaptation
12. Cardiopulmonary Adaptation to High Altitude
13. Cardiac Hypertrophy in Hypertension
14. Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice
15. The Athlete""s Heart
Part III Molecular and Cellular Aspects of Cardiac Adaptations
16. Role of b-Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy
17. Role of Phospholipase C in the a1-Adrenoceptor Mediated Cardiac Hypertrophy
18. Cardiac Remodeling in the Hypertrophic Heart: Signal-Dependent Regulation of the Fibrotic Gene Program by CLP-1
19. Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy
20. Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection
21. Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor
22. Myocardial Adaptation and Autophagy
23. Modulatory Role of VEGF in Angiogenesis for Cell Survival
24. The Role of CaM Kinase II in Cardiac Function in Health and Disease
