DESCRIPTION:
Rapid progress in the definition of tumour antigens, and improved immunisation methods, bring effective cancer vaccines within reach. In this wide-ranging survey, clinicians and scientists at the forefront of these developments review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, chapters cover the rationale, development and implementation of vaccines in human cancers generally, and with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. Target identification, delivery vectors and clinical trial design are reviewed, and the book begins and ends with lucid overviews from the editors, including the most recent developments. Encapsulating recent scientific progress and the likely clinical potential of cancer vaccines, this book provides an essential introduction and guide for oncologists, immunologists and indeed all clinicians treating cancer patients.
CONTENTS:
1. Immunity and cancer.
2. Immunotherapy of bladder cancer.
3. Poxviruses as vectors for cancer immunotherapy.
4. Vaccina-based human papilloma virus vaccines.
5. Vaccine delivery and immuno suppression in cervical cancer.
6. Vaccines for colon cancer.
7. Muci vaccines and breast cancer.
8. Anti-idiotypic vaccination.
9. Immunotherapy and vaccination against EpsteinâÇ"Barr virus-associated cancer.
10. Serologically identified tumour antigens as cancer vaccines Ugur Sahin.
11. CTL-defined cancer vaccines in melanoma and other epithelial cancers.
12. DNA vaccines against B-cell tumours.
13. Dendritic cell approaches to immunotherapy.
14. Overview and recent developments.
