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BIOLOGY OF DEPRESSION- 2 Vols.-9783527307852
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    De 2 a 3 Semanas

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155.77 €

147,98  €

Reported by the WHO and the World Bank to be the fourth cause of disability worldwide, depression can best be explained from a genetic perspective as a complex disorder of gene-environment interactions.

This is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches. In addition, the book covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.

1. Classification of Depression: Research and Diagnostic Criteria: DSM-IV and ICD-10.
2. Psychosocial and Environmental Formulations of Depression.
3. The Economic Burden of Depression: Societal and Patient Perspectives.
4. The Depressive Spectrum: Reconceptualizing the Relationship between Dysthymic, Subthreshold and Major Depressions.
5. The Monoamine Hypothesis of Depression.
6. Monoaminergic-based Pharmacotherapy for Depression.
7. Psychobiology of Electroshock.
8. Current Prognosis of Depression.
9. Treatment of Depression in Medical Illness.
10. Depression and Suicidality in Children and Adolescents.
11. The Biology and Genetics of Suicidality.
12. Geriatric Depression.
13. Comorbidity of Depression and Substance Abuse.
14. Depression in the Context of Cancer.
15. Treatment of Refractory Depression.
16. Clinical Pharmacology of New Classes of Antidepressant Drugs.
17. Neuroimaging and Neuropathological Studies of Mood Disorders.
18. Dysregulation of Circadian Rhythms in Mood Disorders: Molecular Mechanisms.
19. Neuropeptidergic Dysfunction in Depression.
20. Depression, Mania, and Thyroid Function: A Story of Intimate Relationships.
21. Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities.
22. Neuroimmune Mediators: Are Cytokines Mediators of Depression?.
23. Borna Disease Virus: Impact on Mood and Cognition.
24. Depression and Heart Disease.
25. Genetic Substrates Shared by Depression and Cardiovascular Disease.
26. History and Epidemiology of Depression.
27. Major Depression and Animals Models.
28. Loss and Deprivation: From Animal Models to Clinical Presentation.
29. Neurogenomics of depression.
30. Genetic Approaches to Depression: Linkage Studies.
31. Genetic Approaches to Depression: Association Studies.
32. Molecular Effects of Antidepressant Treatments.
33. The Role of Transcription Factors in the Biology of Depression.
34. Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action.
35. Pharmacogenetics of Antidepressant Drug Metabolism and Its Clinical Implications.
36. Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response.
37. Emerging Treatments for Depression: Beyond the Monoamine Hypothesis.
38. Antidepressants and Suicide: Clinical Considerations.
39. Depression in Developing Countries.
40. Complementary and Alternative Medical Treatment for Depression.
41. The Experience of Depression.

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