DESCRIPTION:
This book provides an update on the current understanding of various aspects of bladder cancer biology and introduces clinical manifestations together with current and novel treatment aspects.
Key concepts covered include epidemiology and genetic predisposition to bladder cancer, insights into the mutational events and molecular pathogenesis of bladder cancer, detailed analyses of tumor subtypes, and references to common experimental models used in the study of bladder cancer. The book addresses critical issues such as the molecular features that contribute to the development of bladder cancer, the impact of the tumor microenvironment on disease progression, and the potential of novel urine- and blood-based biomarkers for diagnosis and treatment. Innovative therapeutic applications are also explored, including targeting immune checkpoints and personalized medicine approaches.
Aimed at early career and experienced researchers or clinicians alike, this volume provides an interdisciplinary understanding of bladder cancer. Delving into the biology, pathology, and clinical aspects of the disease, it serves as an indispensable resource for understanding bladder cancer""s complexity.
CONTENTS:
Fundamentals of Bladder Cancer
Epidemiology of Bladder Cancer
Genetic Predisposition to Bladder Cancer
Human Urothelium
Bladder Cancer Pathology
Overview of Standard Therapy of Non-Muscle-Invasive Bladder Cancer
Overview of Standard Therapy of Muscle-Invasive Bladder Cancer
Molecular Genetics and Oncogenesis in Bladder Cancer
From Normalcy to Neoplasia: Mutational Events During Bladder Tumor Evolution
Cell Cycle Regulators as Oncogenic Drivers in Bladder Cancer
DNA Repair Pathway Alterations in Bladder Cancer
DNA Methylation and Chromatin Regulators in Bladder Cancer
Pathogenesis and Microenvironment Dynamics in Bladder Cancer
Molecular Pathogenesis: Field Cancerization and Clonal Evolution in Urothelial Cancer Initiation and Progression
The Bladder Tumor Microenvironment
Molecular and Histological Subtypes of Bladder Cancer
Molecular Subtypes of Non-Muscle-Invasive Bladder Cancer
Molecular Subtypes of Muscle-Invasive Bladder Cancer
Molecular Features of Divergent Differentiation and Histological Subtypes in Bladder Cancer
Experimental Models of Bladder Cancer
The Emerging Landscape of Mouse Bladder Cancer Models
In Vitro Bladder Cancer Models
Biomarkers for Diagnosis and Treatment of Bladder Cancer
Urine Biomarkers for Bladder Cancer Diagnosis and Screening
Blood-Based Biomarkers for Bladder Cancer Diagnosis and Prognosis
Mechanisms and Biomarkers of Response to BCG and Chemotherapy in Bladder Cancer
Therapeutic Application Based on Molecular Insights
New Treatment Approaches in Non-Muscle-Invasive Bladder Cancer
New Treatment Approaches in Muscle-Invasive Bladder Cancer
Targeting the Immune Checkpoint in Bladder Cancer
Future Directions in Bladder Cancer Research
Future Directions in Bladder Cancer Research and Clinical Implications
